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Systems Biology

Systems Biology

  1. Melanie Boerries1,
  2. Roland Eils2,
  3. Hauke Busch1

Published Online: 10 OCT 2011

DOI: 10.1002/3527600906.mcb.200500051.pub2

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Boerries, M., Eils, R. and Busch, H. 2011. Systems Biology. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. 1

    Freiburg Institute for Advanced Studies – LifeNet, School of Life Sciences, Freiburg, Germany

  2. 2

    German Cancer Research Institute, Heidelberg, Germany

Publication History

  1. Published Online: 10 OCT 2011

Abstract

Systems Biology is a new field of biology, which places the theoretical foundations of systems analysis of living matter into the context of modern high-throughput quantitative experimental data, mathematics, and in silico simulations. The aim is to analyze the organization and to gain engineering-control of metabolic and genetic pathways. The ultimate goal is to gain an “holistic” view of the complex workings of life. The need for a system level understanding of biology is reviewed in this chapter, and comments are provided on the current scientific progress in this field. The current and future directions of experimental design strategies and theoretical approaches are also highlighted.

Keywords:

  • Systems biology;
  • Synthetic biology;
  • Network biology;
  • System;
  • Systems theory;
  • Robustness;
  • Control;
  • Modularity;
  • Model