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Stem Cells, Adult

Cell Biology

  1. Jason H. Pomerantz1,
  2. Jason H. Pomerantz2,
  3. Helen M. Blau3

Published Online: 15 SEP 2006

DOI: 10.1002/3527600906.mcb.200500073

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Pomerantz, J. H., Pomerantz, J. H. and Blau, H. M. 2006. Stem Cells, Adult. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. 1

    University of California, San Francisco, CA, USA

  2. 2

    Stanford University School of Medicine, Stanford, CA, USA

  3. 3

    Stanford University School of Medicine, Stanford, CA, USA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Stem cells are responsible for providing a source of differentiated cells in adult tissues that undergo renewal or repair. Considerable progress has been made recently in the identification and characterization of stem cells in adults. They have been the focus of intense interest because of their potential therapeutic use in restoring form and function to damaged tissues. Stem cells in postnatal animals have been identified in specific locales, but another promising and less well-characterized population of stem cells are circulating cells derived from the bone marrow (BMDC). Advances in nuclear transplantation and the observed plasticity of gene expression and phenotype reported in multiple phyla, show that adult cells, including derivatives of HSCs, have a remarkable capacity to be reprogrammed. Irrespective of the mechanism by which reprogramming occurs, fusion or differentiation in response to the microenvironment, the potential for new gene expression patterns by BMDC (bone marrow–derived cell) progeny in recipient tissues holds promise for developing cellular therapies for both proliferative and postmitotic tissues.

Keywords:

  • Bone Marrow–Derived Cell;
  • Cloning;
  • Heterokaryon;
  • Programming;
  • Reprogramming