Dynamics of Biomolecular Networks
Published Online: 15 MAR 2012
Copyright © 2012 Wiley-VCH Verlag GmbH & Co. KGaA
Encyclopedia of Molecular Cell Biology and Molecular Medicine
How to Cite
Cozzo, E., Sanz, J. and Moreno, Y. 2012. Dynamics of Biomolecular Networks. Encyclopedia of Molecular Cell Biology and Molecular Medicine. .
- Published Online: 15 MAR 2012
During the past few years, whilst the capacity to produce large amounts of experimental data has increased dramatically, the ability to analyze these data has not progressed at the same pace. Thus, there is a risk that this sea of acquired data will become overwhelming, and that no meaningful theoretical or phenomenological insights will be extracted from it. One way to overcome such a problem would be to study the interactions among a system's constituents as a network, involving both the structure and dynamics of that system. In this chapter, the main approaches used to model the dynamical behavior of biomolecular, regulatory gene networks are revised, whereby two different approaches are discussed and analyzed: (i) the discrete case, as represented by Boolean functions; and (ii) the continuous case, which is based on differential equations. For both scenarios, the most recent results are outlined, and details provided of the many variants that can be adopted. Finally, the future lines of research in this field are proposed.
- Boolean network;
- Biologically relevant Boolean functions;
- Network inference;
- Probabilistic Boolean network (PBN);
- Rate equation;
- AND/OR logical functions;
- Network motif