Standard Article

Induced Pluripotent Stem Cells

Stem Cells

  1. Kazutoshi Takahashi1,
  2. Shinya Yamanaka1,2,3

Published Online: 30 OCT 2012

DOI: 10.1002/3527600906.mcb.201100023

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Takahashi, K. and Yamanaka, S. 2012. Induced Pluripotent Stem Cells. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. 1

    Kyoto University, Center for iPS Cell Research and Application, Kyoto, Japan

  2. 2

    Japan Science and Technology Agencyn, Yamanaka iPS Cell Special Project, Saitama, Japan

  3. 3

    Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA

Publication History

  1. Published Online: 30 OCT 2012

Abstract

The fate of somatic cells can be converted to the pluripotent state by the combination of a few transcription factors. This technology is expected to overcome the issues of embryonic stem cells. In addition, such reprogrammed cells, when derived from genetic disorders, may contribute towards an understanding of pathogenesis. In this chapter, the past, present and future of reprogramming are introduced, together with details of induced pluripotent stem cells (iPSCs).

Keywords:

  • Reprogramming;
  • Pluripotency;
  • iPSCs