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Epigenetic Regulation and Epigenomics

  1. Pao-Yang Chen,
  2. Matteo Pellegrini

Published Online: 15 MAY 2012

DOI: 10.1002/3527600906.mcb.201100028

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Chen, P.-Y. and Pellegrini, M. 2012. Methylomes. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. University of California, Department of Molecular Cell and Developmental Biology, Los Angeles, CA, USA

Publication History

  1. Published Online: 15 MAY 2012


The article contains sections titled:

  • An Introduction to Methylomes
  • Technology
    • Affinity Enrichment-Based Methods
    • Enzyme Digestion-Based Methods
    • Bisulfite Conversion-Based Methods
      • Bisulfite Sequencing
      • GoldenGate
      • Infinium HumanMethylation27
      • Bisulfite Padlock Probe
      • Whole-Genome Bisulfite Sequencing
      • Reduced Representation Bisulfite Sequencing
    • Comparison of Methods
    • Aligning Bisulfite-Converted Reads
      • Three-Letter Alignment Algorithm
    • Downstream Data Analyses
  • Applications
    • The First Arabidopsis Methylome Using BS-Seq
    • Human Methylomes from Embryonic Stem Cells
      • The First Look at the Human Methylome
      • Vertical Comparison between ES Cells and i PSCs
    • Phylogenetically Diverse Methylomes
      • Global Methylation Patterns
      • Gene Methylation
      • Transposable Elements (TEs) Methylation
  • Future Directions
    • Pacific Bioscience Direct Readout of DNA Methylation
      • SMRT Sequencing
      • Direct Detection of DNA Methylation
    • Perspectives of Methylome Studies


  • DNA methylation;
  • CpG islands;
  • DNA methyltransferase (DNMT);
  • Hydroxymethylation;
  • Promoter methylation;
  • Gene body methylation;
  • Repetitive sequences