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Cardiomyocytes from Human Embryonic Stem Cells

Stem Cells

  1. Xiu Qin Xu1,
  2. Manasi Nandihalli2,
  3. Kar Tong Tan3,
  4. William Sun4,5

Published Online: 10 FEB 2013

DOI: 10.1002/3527600906.mcb.201200007

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Xu, X. Q., Nandihalli, M., Tan, K. T. and Sun, W. 2013. Cardiomyocytes from Human Embryonic Stem Cells. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. 1

    Xiamen University, Institute of Stem Cell and Regenerative Medicine, Medical College, Xiamen, Fujian Province, PR China

  2. 2

    National Heart Centre Singapore, Research and Development Unit, Mistri Wing, Singapore

  3. 3

    National University of Singapore, Department of Biological Sciences, Singapore

  4. 4

    Agency for Science, Technology and Research, Experimental Therapeutics Centre, #03-01 Nanos, Singapore

  5. 5

    National University of Singapore, Department of Physiology, Yong Loo Lin School of Medicine, Singapore

Publication History

  1. Published Online: 10 FEB 2013

Abstract

Human embryonic stem cells (hESCs) are self-renewing and pluripotent cells that can differentiate into functional cardiomyocytes in vitro. Significant progress has been made over the past decade in improving the differentiation and enrichment of hESC-derived cardiomyocytes. These cells allow investigations into human cardiac biology, and have great potential for applications in cell therapy and drug discovery. However, several technical hurdles must be overcome before their routine use as therapeutic agents or as cellular models for drug screening. This is an exciting area of stem cell research that will have a major impact on cardiovascular medicine.

Keywords:

  • Blastocyst;
  • Gastrulation;
  • Pluripotent;
  • Reprogramming;
  • Myocardial infarction;
  • QT interval;
  • Teratoma;
  • Torsades de Pointes;
  • Xenogeneic