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Stem Cell-Based Approaches to Spinal Cord Injury

Stem Cells

  1. Alexa L. Reeves,
  2. Hans Keirstead

Published Online: 10 FEB 2013

DOI: 10.1002/3527600906.mcb.201200013

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Reeves, A. L. and Keirstead, H. 2013. Stem Cell-Based Approaches to Spinal Cord Injury. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. University of California Irvine, Department of Neurological Surgery, Orange, CA, USA

Publication History

  1. Published Online: 10 FEB 2013

Abstract

Stem cells have great potential for the treatment of spinal cord injury (SCI). Different types of stem cell include somatic and embryonic, both of which have unique advantages and disadvantages. Here, the profile of motor neuron progenitor cells and oligodendrocyte progenitor cells derived from human embryonic stem cells is discussed, and several significant animal model experiments using both cell types are reviewed. Clinical trials currently underway or planned using these cell types for SCI therapy will also be discussed. Finally, it is proposed that these cell types may be the most useful and clinically applicable for human therapeutic use.

Keywords:

  • Bone marrow stromal cell;
  • Embryonic stem cell;
  • Human embryonic stem cell-derived motor neuron progenitor cell;
  • Human embryonic stem cell-derived oligodendrocyte progenitor cell;
  • Induced pluripotent stem cell;
  • Neural progenitor cell;
  • Neural stem cell;
  • Spinal cord injury