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Therapeutics against Cancer Stem Cells: Targeting the Root of Cancer

Stem Cells

  1. Kristen M. Smith1,2,
  2. Catriona H. M. Jamieson2

Published Online: 10 FEB 2013

DOI: 10.1002/3527600906.mcb.201200014

Reviews in Cell Biology and Molecular Medicine

Reviews in Cell Biology and Molecular Medicine

How to Cite

Smith, K. M. and Jamieson, C. H. M. 2013. Therapeutics against Cancer Stem Cells: Targeting the Root of Cancer. Reviews in Cell Biology and Molecular Medicine. .

Author Information

  1. 1

    University of California, San Diego, Department of Medicine and Moores UCSD Cancer Center, La Jolla, California, USA

  2. 2

    Eclipse Therapeutics, San Diego, California, USA

Publication History

  1. Published Online: 10 FEB 2013

Abstract

The cancer stem cell hypothesis provides a useful framework with which to investigate the mechanisms of cancer initiation, progression, and treatment. Cells with stem cell-like properties have been implicated in tumor initiation, metastatic spread and disease evolution, as well therapeutic failure. While the roles of cancer stem cells continue to be defined, known stem cell signaling pathways and stem cell niche-regulated mechanisms of survival are emerging as targets to selectively eliminate cancer stem cells. In this chapter, these mechanisms and approaches for targeting cancer stem cells through these pathways will be discussed. Strategies will also be addressed for identifying novel pathways involved in cancer stem cell survival, and requirements for the clinical evaluation of cancer stem cell-targeted therapies.

Keywords:

  • Cancer stem cell;
  • Self-renewal