Chapter 10. Apoptosis in Rheumatoid Arthritis
- Prof. Dr. Dr. Joachim R. Kalden2,
- Dr. Dr. Martin Herrmann3
Published Online: 16 SEP 2004
DOI: 10.1002/3527601457.ch10
Copyright © 2003 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Apoptosis and Autoimmunity
Additional Information
How to Cite
Yamanishi, Y. and Firestein, G. S. (2004) Apoptosis in Rheumatoid Arthritis, in Apoptosis and Autoimmunity (eds J. R. Kalden and M. Herrmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601457.ch10
Editor Information
- 2
University of Erlangen-Nuremberg, Department of Internal Medicine III and Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany
- 3
University of Erlangen-Nuremberg, Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany
Publication History
- Published Online: 16 SEP 2004
- Published Print: 1 DEC 2002
ISBN Information
Print ISBN: 9783527304424
Online ISBN: 9783527601455
- Summary
- Chapter
Keywords:
- rheumatoid arthritis;
- synovial fluid T cells;
- RA synovium;
- cytokines;
- therapeutic target of molecules
Summary
Introduction
Apoptosis in RA Synovium
Apoptosis in Synovial Fluid T Cells
Regulation of Apoptosis by Cytokines
p53 Mutations in RA Synovium and Fibroblast-like Synoviocytes
The Role and Regulation of p53 Tumor Suppressor Protein
p53 Protein Expression in Inflammation
p53 Mutations in RA Synovial Tissue
Possible Mechanism of Occurrence of p53 Mutations
Function of p53 Mutations in RA Synovial Cells
Fas-Fas Ligand (FasL) Apoptotic Pathway in RA
Fas and FasL
Fas-FasL Expression in Synovium
Fas-FasL Expression in Synovial Fluid Cells
sFas
sFasL
Fas-Mediated Apoptosis
Therapeutic Target of Molecules for Inducing Apoptosis in Synovial Tissues
Fas-FasL and Related Molecules
Nuclear Factor (NF)-κB and Related Molecules
p53 Tumor Suppressor Gene
Proteasome
Conclusion
References