Chapter 10. Apoptosis in Rheumatoid Arthritis

  1. Prof. Dr. Dr. Joachim R. Kalden2 and
  2. Dr. Dr. Martin Herrmann3
  1. Yuji Yamanishi and
  2. Gary S. Firestein

Published Online: 16 SEP 2004

DOI: 10.1002/3527601457.ch10

Apoptosis and Autoimmunity

Apoptosis and Autoimmunity

How to Cite

Yamanishi, Y. and Firestein, G. S. (2002) Apoptosis in Rheumatoid Arthritis, in Apoptosis and Autoimmunity (eds J. R. Kalden and M. Herrmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601457.ch10

Editor Information

  1. 2

    University of Erlangen-Nuremberg, Department of Internal Medicine III and Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

  2. 3

    University of Erlangen-Nuremberg, Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

Author Information

  1. University of California, MEDCTR/Rheumatology, 9500 Gilman Drive BSB 5064, La Jolla, CA 92093-0656, USA

Publication History

  1. Published Online: 16 SEP 2004
  2. Published Print: 1 DEC 2002

ISBN Information

Print ISBN: 9783527304424

Online ISBN: 9783527601455



  • rheumatoid arthritis;
  • synovial fluid T cells;
  • RA synovium;
  • cytokines;
  • therapeutic target of molecules


  • Introduction

  • Apoptosis in RA Synovium

  • Apoptosis in Synovial Fluid T Cells

  • Regulation of Apoptosis by Cytokines

  • p53 Mutations in RA Synovium and Fibroblast-like Synoviocytes

    • The Role and Regulation of p53 Tumor Suppressor Protein

    • p53 Protein Expression in Inflammation

    • p53 Mutations in RA Synovial Tissue

    • Possible Mechanism of Occurrence of p53 Mutations

    • Function of p53 Mutations in RA Synovial Cells

  • Fas-Fas Ligand (FasL) Apoptotic Pathway in RA

    • Fas and FasL

    • Fas-FasL Expression in Synovium

    • Fas-FasL Expression in Synovial Fluid Cells

    • sFas

    • sFasL

    • Fas-Mediated Apoptosis

  • Therapeutic Target of Molecules for Inducing Apoptosis in Synovial Tissues

    • Fas-FasL and Related Molecules

    • Nuclear Factor (NF)-κB and Related Molecules

    • p53 Tumor Suppressor Gene

    • Proteasome

  • Conclusion

  • References