Chapter 11. Systemic Lupus Erythematosus

  1. Prof. Dr. Dr. Joachim R. Kalden2,
  2. Dr. Dr. Martin Herrmann3
  1. Thomas D. Beyer1,
  2. Susanne Kuenkele1,
  3. Udo S. Gaipl1,
  4. Wasilis Kolowos1,
  5. Reinhard E. Voll1,
  6. Irith Baumann1,
  7. Prof. Dr. Dr. Joachim R. Kalden2,
  8. Dr. Dr. Martin Herrmann3

Published Online: 16 SEP 2004

DOI: 10.1002/3527601457.ch11

Book Title

Apoptosis and Autoimmunity

Apoptosis and Autoimmunity

Additional Information

How to Cite

Beyer, T. D., Kuenkele, S., Gaipl, U. S., Kolowos, W., Voll, R. E., Baumann, I., Kalden, J. R. and Herrmann, M. (2004) Systemic Lupus Erythematosus, in Apoptosis and Autoimmunity (eds J. R. Kalden and M. Herrmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601457.ch11

Editor Information

  1. 2

    University of Erlangen-Nuremberg, Department of Internal Medicine III and Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

  2. 3

    University of Erlangen-Nuremberg, Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

Author Information

  1. 1

    Universität Erlangen-Nürnberg, Institut für Klinische Immunologie, Medizinische Klinik III, Krankenhausstraße 12, 91054 Erlangen, Germany

  2. 2

    University of Erlangen-Nuremberg, Department of Internal Medicine III and Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

  3. 3

    University of Erlangen-Nuremberg, Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

Publication History

  1. Published Online: 16 SEP 2004
  2. Published Print: 1 DEC 2002

ISBN Information

Print ISBN: 9783527304424

Online ISBN: 9783527601455

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Keywords:

  • systemic lupus erythematosus;
  • B cells;
  • T cells;
  • genetic factors;
  • animal models;
  • reduced phagocytosis;
  • germinal center reaction

Summary

  • Introduction

  • Involvement of B Cells in the Development of SLE

  • Involvement of T Cells in the Development of SLE

  • Genetic Factors for the Development of SLE

  • Animal Models for the Immunogenicity of Dying Cells

  • Phagocytosis of Apoptotic Cells

  • Reduced Phagocytosis of Apoptotic Cells in SLE Patients Challenges T Cell Tolerance

    • Increased Apoptosis in SLE Patients?

    • Reduced Phagocytosis of Apoptotic Cells by In Vitro Generated Macrophages from SLE Patients

    • Hypothesis: Accumulation of Secondary Necrotic Cells Challenges T Cell Tolerance in SLE

  • The Germinal Center Reaction

  • Reduced Phagocytosis of Apoptotic Cells in SLE Patients Challenges B Cell Tolerance

    • The Number of Tingible Body Macrophages is Reduced in the Germinal Centers of SLE Patients

    • Accumulation of Apoptotic Cell-Derived Nuclear Fragments in the Germinal Centers of SLE Patients

    • Hypothesis: Accumulation of Apoptotic Dell-Derived Nuclear Fragments in the Germinal Centers Challenges B Cell Tolerance in SLE

  • Conclusion

  • References

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