Chapter 12. Dendritic Cells Pulsed with Apoptotic Tumor Cells as Vaccines

  1. Prof. Dr. Dr. Joachim R. Kalden2,
  2. Dr. Dr. Martin Herrmann3
  1. Lars Jenne,
  2. Birthe Sauter

Published Online: 16 SEP 2004

DOI: 10.1002/3527601457.ch12

Book Title

Apoptosis and Autoimmunity

Apoptosis and Autoimmunity

Additional Information

How to Cite

Jenne, L. and Sauter, B. (2004) Dendritic Cells Pulsed with Apoptotic Tumor Cells as Vaccines, in Apoptosis and Autoimmunity (eds J. R. Kalden and M. Herrmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601457.ch12

Editor Information

  1. 2

    University of Erlangen-Nuremberg, Department of Internal Medicine III and Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

  2. 3

    University of Erlangen-Nuremberg, Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

Author Information

  1. Universität Erlangen-Nürnberg, Dermatologische Klinik mit Poliklinik, Hartmannstraße 14, 91052 Erlangen, Germany

Publication History

  1. Published Online: 16 SEP 2004
  2. Published Print: 1 DEC 2002

ISBN Information

Print ISBN: 9783527304424

Online ISBN: 9783527601455

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CHAPTER TOOLS

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Keywords:

  • dendritic cells (DCs) as vaccines;
  • immature DCs;
  • mature DCs;
  • immunomodulation;
  • antigen loading;
  • apoptotic tumor cells

Summary

  • Introduction

  • Immature DCs

    • Immature DCs Capture Antigen

    • Phagocytosis of Apoptotic Cells

    • Processing of Apoptotic Cells

  • Mature DCs

    • Mature DCs Present Antigen and Prime T Lymphocytes

    • Cross-Priming of CD8+ T Cells

    • Cross-Priming versus Cross-Tolerance

  • Immunomodulating Properties of Apoptotic Cells

  • Antigen Loading

  • Apoptotic Tumor Cells for Loading

    • Melanoma

    • Solid Tumors: Breast Cancer, Ovarian Cancer, Colorectal Cancer and Lung Cancer

    • Prostate Cancer

    • Hematological Malignancies

    • Neurological Tumors

    • Renal Cell Carcinoma (RCC)

    • Squamous Cell Carcinoma of the Head and Neck (SCCHN)

  • Concluding Remarks

  • References

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