Chapter 14. Autoantigens as Substrates for Apoptotic Proteases: Implications for the Pathogenesis of Systemic Autoimmune Disease

  1. Prof. Dr. Dr. Joachim R. Kalden2,
  2. Dr. Dr. Martin Herrmann3
  1. Antony Rosen,
  2. Livia Casciola-Rosen

Published Online: 16 SEP 2004

DOI: 10.1002/3527601457.ch14

Book Title

Apoptosis and Autoimmunity

Apoptosis and Autoimmunity

Additional Information

How to Cite

Rosen, A. and Casciola-Rosen, L. (2004) Autoantigens as Substrates for Apoptotic Proteases: Implications for the Pathogenesis of Systemic Autoimmune Disease, in Apoptosis and Autoimmunity (eds J. R. Kalden and M. Herrmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601457.ch14

Editor Information

  1. 2

    University of Erlangen-Nuremberg, Department of Internal Medicine III and Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

  2. 3

    University of Erlangen-Nuremberg, Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

Author Information

  1. The Johns Hopkins University School of Medicine, Departments of Medicine and Pathology, Cell Biology and Anatomy, 720 Rutland Avenue Baltimore, MD 21205-2196, USA

Publication History

  1. Published Online: 16 SEP 2004
  2. Published Print: 1 DEC 2002

ISBN Information

Print ISBN: 9783527304424

Online ISBN: 9783527601455

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CHAPTER TOOLS

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Keywords:

  • systemic autoimmune disease;
  • autoantigens;
  • autoantibodies;
  • caspases;
  • novel autoantigen fragments;
  • defects in clearance

Summary

  • Autoantibodies: Probes of the Perturbed State

  • Lupus Autoantigens Undergo a Striking Redistribution during Apoptosis, Becoming Clustered and Concentrated in the Surface Blebs of Apoptotic Cells

  • Susceptibility to Efficient Cleavage by Caspases unifies a Subgroup of Systemic Disease Autoantigens

  • Novel Autoantigen Fragments are Produced during Cytotoxic Lymphocyte-induced Target Cell Apoptosis

  • Caspase-independent Cell Death: Role in Generating Unique Autoantigen Structure?

  • Defects in Clearance of the Apoptotic Corpse in Tissues May be an Important Defect Underlying Systemic Autoimmune Diseases

  • Model of Systemic Autoimmunity

  • Acknowledgments

  • References

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