Chapter 15. Distinct Cleavage Products of Nuclear Autoantigens in Apoptosis and Necrosis: Implications for Autoimmunity

  1. Prof. Dr. Dr. Joachim R. Kalden2,
  2. Dr. Dr. Martin Herrmann3
  1. Carlos A. Casiano,
  2. Christine Molinaro,
  3. Sheldon Holder,
  4. Xiwei Wu

Published Online: 16 SEP 2004

DOI: 10.1002/3527601457.ch15

Book Title

Apoptosis and Autoimmunity

Apoptosis and Autoimmunity

Additional Information

How to Cite

Casiano, C. A., Molinaro, C., Holder, S. and Wu, X. (2004) Distinct Cleavage Products of Nuclear Autoantigens in Apoptosis and Necrosis: Implications for Autoimmunity, in Apoptosis and Autoimmunity (eds J. R. Kalden and M. Herrmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601457.ch15

Editor Information

  1. 2

    University of Erlangen-Nuremberg, Department of Internal Medicine III and Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

  2. 3

    University of Erlangen-Nuremberg, Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

Author Information

  1. Loma Linda University, Department of Biochemistry and Microbiology, Division of Microbiology and Molecular Genetics, Center for Molecular Biology and Gene Therapy and Department of Medicine Section of Rheumatology, 11085 Campus Street, Mortensen Hall 132, Loma Linda, CA 92350, USA

Publication History

  1. Published Online: 16 SEP 2004
  2. Published Print: 1 DEC 2002

ISBN Information

Print ISBN: 9783527304424

Online ISBN: 9783527601455

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Keywords:

  • autoimmunity;
  • autoantigen cleavage;
  • cleavage products of autoantigens;
  • apoptosis;
  • necrosis;
  • immunity

Summary

  • Introduction

  • The Multiple Faces of Cell Death

    • Apoptosis

    • Necrosis

    • Caspase-independent Cell Death

  • Autoantigen Cleavage in Apoptosis

  • Autoantigen Cleavage in Non-apoptotic Cell Death

    • Autoantigen Cleavage during Primary Necrosis

    • Autoantigen Cleavage during Secondary Necrosis

    • Autoantigen Cleavage during Caspase-independent Cell Death

  • Implications of Autoantigen Cleavage for Autoimmunity

    • Immunogenicity of Apoptotic Cells

    • Immunogenicity of Necrotic Cells

    • Apoptosis, Necrosis and Immunity to Intracellular Antigens

    • Modified Autoantigens and Defective Phagocytic Function

  • Conclusions

  • Acknowledgments

  • References

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