Chapter 2. Caspase Knockouts: Matters of Life and Death

  1. Prof. Dr. Dr. Joachim R. Kalden3,
  2. Dr. Dr. Martin Herrmann4
  1. Saquib Lakhani1,
  2. Binfeng Lu2,
  3. Richard A. Flavell2

Published Online: 16 SEP 2004

DOI: 10.1002/3527601457.ch2

Book Title

Apoptosis and Autoimmunity

Apoptosis and Autoimmunity

Additional Information

How to Cite

Lakhani, S., Lu, B. and Flavell, R. A. (2004) Caspase Knockouts: Matters of Life and Death, in Apoptosis and Autoimmunity (eds J. R. Kalden and M. Herrmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601457.ch2

Editor Information

  1. 3

    University of Erlangen-Nuremberg, Department of Internal Medicine III and Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

  2. 4

    University of Erlangen-Nuremberg, Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany

Author Information

  1. 1

    Yale University Section of Immunobiology, 330 Cedar Street, PO Box 208011, New Haven, CT 06520, USA

  2. 2

    Yale University School of Medicine, Howard Hughes Medical Institute and Section of Immunobiology, 330 Cedar Street, PO Box 208011, New Haven, CT 06520, USA

Publication History

  1. Published Online: 16 SEP 2004
  2. Published Print: 1 DEC 2002

ISBN Information

Print ISBN: 9783527304424

Online ISBN: 9783527601455

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CHAPTER TOOLS

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Keywords:

  • caspases;
  • activation;
  • caspase knockouts;
  • signaling pathways

Summary

  • Death, Development and Immune Function

  • Apoptotic Pathways: from Nematode to Mammals

  • Triggering a Killer: General Aspects of Caspase Activation

  • Caspase-1 and -11: More than Mediators of Inflammatory Cytokines?

  • Caspase-8 and the FAS Signaling Pathway

  • Caspase-3: The Chief Executioner?

  • Caspase-9: Mitochondrial Activation and the Apoptosome

  • Caspase-2: A Duality of Function

  • Caspase-12: Responding to Stress

  • Compensatory Caspase Activation: A Caveat to Knockout Analysis

  • Caspases: More than Simple Killers

  • Concluding Remarks

  • References

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