Chapter 7. Innate Immunity and Apoptosis: CD14-Dependent Clearance of Apoptotic Cells
- Prof. Dr. Dr. Joachim R. Kalden2,
- Dr. Dr. Martin Herrmann3
Published Online: 16 SEP 2004
DOI: 10.1002/3527601457.ch7
Copyright © 2003 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Apoptosis and Autoimmunity
Additional Information
How to Cite
Gregory, C. D. and Devitt, A. (2004) Innate Immunity and Apoptosis: CD14-Dependent Clearance of Apoptotic Cells, in Apoptosis and Autoimmunity (eds J. R. Kalden and M. Herrmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601457.ch7
Editor Information
- 2
University of Erlangen-Nuremberg, Department of Internal Medicine III and Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany
- 3
University of Erlangen-Nuremberg, Institute for Clinical Immunology Krankenhausstraße 12 91054 Erlangen, Germany
Publication History
- Published Online: 16 SEP 2004
- Published Print: 1 DEC 2002
ISBN Information
Print ISBN: 9783527304424
Online ISBN: 9783527601455
- Summary
- Chapter
Keywords:
- innate immunity;
- clearance of apoptotic cells;
- CD14
Summary
Introduction: CD14, A Multifunctional Molecule involved in Innate Immune Responses
Background
Molecular Structure and Distribution of CD14
CD14 as an LPS Receptor that Signals LPS Responses
CD14 Binds Multiple and Diverse Ligands
Evidence that Apoptotic Cells Interact with CD14
61D3, a CD14 Monoclonal Antibody that Blocks Apoptotic Cell Clearance
Exogenous Expression of CD14 in Non-myeloid Cells
Apoptotic Cell-associated Ligands of CD14
Mechanisms: Conceptualizing CD14's Role in Apoptotic Cell Clearance
CD14 as a PRR that Recognizes Apoptotic Cell-associated Molecular Patterns (ACAMPs)
Differential CD14 Signaling following Ligand Binding
Conclusions: Relative Importance of CD14 in Apoptotic Cell Clearance
References