Chapter 7. Pharmacotherapy for Opioid Withdrawal

  1. Prof. Dr. Mats Berglund2,
  2. Dr. Sten Thelander Project Manager3 and
  3. Prof. Dr. Egon Jonsson Executive Director3
  1. Björn Axel Johansson

Published Online: 15 APR 2004

DOI: 10.1002/3527601465.ch7

Treating Alcohol and Drug Abuse: An Evidence Based Review

Treating Alcohol and Drug Abuse: An Evidence Based Review

How to Cite

Johansson, B. A. (2003) Pharmacotherapy for Opioid Withdrawal, in Treating Alcohol and Drug Abuse: An Evidence Based Review (eds M. Berglund, S. Thelander and E. Jonsson), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601465.ch7

Editor Information

  1. 2

    University Hospital MAS, Alcohol and Drug Clinic, S-20502 Malmö, Sweden

  2. 3

    SBU, Box 5650, S-11486 Stockholm, Sweden

Author Information

  1. Malmö, Sweden

Publication History

  1. Published Online: 15 APR 2004
  2. Published Print: 26 SEP 2003

ISBN Information

Print ISBN: 9783527306824

Online ISBN: 9783527601462

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Keywords:

  • pharmacotherapy;
  • opioid withdrawal;
  • adrenergic agonists;
  • clonidine;
  • placebo;
  • methadone;
  • buprenorphine;
  • doxepin;
  • opioid agonists;
  • methadone;
  • propoxyphene;
  • chlordiazepoxide;
  • naltrexone;
  • naloxone;
  • dopamine agonists

Summary

This chapter contains sections titled:

  • Background

  • Principles of Withdrawal Treatment

  • Non-Rapid

    • Adrenergic Agonists Clonidine (unless otherwise stated) versus

      • Placebo

      • Methadone

      • Buprenorphine

      • Doxepin

      • Other Adrenergic Agonists

    • Opioid Agonists Methadone versus

      • Placebo

      • Buprenorphine

      • Propoxyphene

      • Chlordiazepoxide

      • Summary (Non-Rapid)

  • Rapid

    • Adrenergic Agonist + Opioid Antagonists Clonidine versus Clonidine + naltrexone/naloxone versus

      • Placebo

      • Buprenorphine

      • Methadone

    • Partial opioid agonist + opioid antagonist + adrenergic agonist

      • Summary (Rapid)

  • Ultra-Rapid (Adrenergic agonist) + opioid antagonist under anesthesia, or under different levels of sedation

    • Naloxone versus Placebo

    • (Clonidine) + Naloxone/Naltrexone under Light Sedation versus Deep Sedation

    • Summary (Ultra-Rapid)

  • Reviews

  • Conclusion

  • Appendix

    • Non-Rapid

      • Adrenergic Agonists

      • Opioid agonists

      • Dopamine agonists

    • Rapid Adrenergic agonist + opioid antagonists

    • Ultra-Rapid (Adrenergic agonists) + opioid antagonists under anesthesia

    • Reviews

    • Conclusion