Chapter 5. At the Controls: Genomic Imprinting and the Epigenetic Regulation of Gene Expression

  1. Dr. Stephan Beck1,
  2. Dr. Alexander Olek2
  1. Anne Ferguson-Smith

Published Online: 16 MAR 2005

DOI: 10.1002/3527601511.ch5

The Epigenome: Molecular Hide and Seek

The Epigenome: Molecular Hide and Seek

How to Cite

Ferguson-Smith, A. (2005) At the Controls: Genomic Imprinting and the Epigenetic Regulation of Gene Expression, in The Epigenome: Molecular Hide and Seek (eds S. Beck and A. Olek), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601511.ch5

Editor Information

  1. 1

    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB 10 1SA, UK

  2. 2

    Epigenomics AG, Kastanienallee 24, 10435 Berlin, Germany

Publication History

  1. Published Online: 16 MAR 2005
  2. Published Print: 21 FEB 2003

ISBN Information

Print ISBN: 9783527304943

Online ISBN: 9783527601516

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Keywords:

  • genomic imprinting;
  • epigenetic regulation;
  • gene expression;
  • DNA methylation;
  • imprinting control regions;
  • chromatin

Summary

This chapter contains sections titled:

  • Introduction

  • Genomic Imprinting

    • The Role of DNA Methylation in Imprinted Gene Expression

    • Organization of Imprinted Genes

    • The Mechanism of Imprinting at the Mouse Igf2r Imprinted Domain Requires a Cis-acting Noncoding Antisense Transcript Regulated by DNA Methylation

    • Imprinting at the Mouse Distal Chromosome 7 Domain Is Regulated by at Least Two Imprinting Control Regions (ICRs) Acting on Different Sets of Genes

    • The Mechanisms of Imprinting at the PWS/AS Imprinted Domain

  • DNA Methylation and Chromatin

  • X Inactivation

  • Prospects and Patterns