Chapter 7. Liver or Broccoli? Food's Lasting Effect on Genome Methylation†

  1. Dr. Stephan Beck1,
  2. Dr. Alexander Olek2
  1. Michael Fenech

Published Online: 16 MAR 2005

DOI: 10.1002/3527601511.ch7

Book Title

The Epigenome: Molecular Hide and Seek

The Epigenome: Molecular Hide and Seek

Additional Information

How to Cite

Fenech, M. (2005) Liver or Broccoli? Food's Lasting Effect on Genome Methylation, in The Epigenome: Molecular Hide and Seek (eds S. Beck and A. Olek), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601511.ch7

Editor Information

  1. 1

    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB 10 1SA, UK

  2. 2

    Epigenomics AG, Kastanienallee 24, 10435 Berlin, Germany

  1. †

    Substantial parts of this paper, including Fig. 7.1 and Table 7.2, were updated and/or reprinted from Mutation Research, vol. 475, Fenech M., “The role of folic acid and vitamin B12 in genomic stability of human cells”, pages 57–67, 2001, with permission of Elsevier Science. – Abbreviations: HC = homocysteine, MN = micronucleus, MNed = micronucleated, RDA = recommended dietary allowance, SSB = single-strand break, DSB = double-strand break, RBCs = red blood cells. – Key to unit conversion: 1 ng/ml folic acid = 2.26 nmol/L folic acid; 1 pg/ml vitamin B12 = 0.74 pmol/L vitamin B12.

Publication History

  1. Published Online: 16 MAR 2005
  2. Published Print: 21 FEB 2003

ISBN Information

Print ISBN: 9783527304943

Online ISBN: 9783527601516

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CHAPTER TOOLS

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Keywords:

  • liver;
  • broccoli;
  • genome methylation;
  • folate;
  • vitamin B12;
  • choline;
  • methionine;
  • folic acid;
  • human cells;
  • bioavailability;
  • recommended dietary allowances

Summary

This chapter contains sections titled:

  • Introduction

  • Important Dietary Sources of Folate, Vitamin B12, Choline, and Methionine

  • Evidence from in Vitro Cultures for the Role of Folic Acid in Genomic Stability of Human Cells

  • Evidence from in Vivo Studies for the Role of Folate and Vitamin B12 in Genomic Stability of Human Cells

  • Environmental and Genetic Factors that Determine the Bioavailability of Folate and Vitamin B12

  • Recommended Dietary Allowances (RDAs) for Folate and Vitamin B12 Based on Genomic Stability

  • Conclusion

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