Acknowledgements: Work in the author's laboratory is supported by grants from the National Institutes of Health, USA, and the George and Barbara Bush Endowment for Innovative Cancer Research.
Chapter 8. Living Longer: The Aging Epigenome
- Dr. Stephan Beck1,
- Dr. Alexander Olek2
Published Online: 16 MAR 2005
DOI: 10.1002/3527601511.ch8
Copyright © 2003 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
The Epigenome: Molecular Hide and Seek
Additional Information
How to Cite
Issa, J.-P. (2005) Living Longer: The Aging Epigenome, in The Epigenome: Molecular Hide and Seek (eds S. Beck and A. Olek), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601511.ch8
Editor Information
- 1
The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB 10 1SA, UK
- 2
Epigenomics AG, Kastanienallee 24, 10435 Berlin, Germany
Publication History
- Published Online: 16 MAR 2005
- Published Print: 21 FEB 2003
ISBN Information
Print ISBN: 9783527304943
Online ISBN: 9783527601516
- Summary
- Chapter
Keywords:
- aging epigenome;
- epigenetic silencing;
- age-related methylation;
- epigenetic mosaicism;
- epithelium
Summary
This chapter contains sections titled:
Introduction
Methylation as a Mark of Epigenetic Silencing
The Dogma: Formation of Methylation Patterns
The Reality: Age-related Methylation and Epigenetic Mosaicism in Normal Epithelium
The Consequences: Methylation and Age-related Diseases
The Bottom Line: Clinical Implications