Chapter 10. Hereditary Spherocytosis (HS)

  1. Prof. Dr. Yoshihito Yawata M.D., Ph.D.

Published Online: 29 APR 2004

DOI: 10.1002/3527601538.ch10

Cell Membrane: The Red Blood Cell as a Model

Cell Membrane: The Red Blood Cell as a Model

How to Cite

Yawata, Y. (2003) Hereditary Spherocytosis (HS), in Cell Membrane: The Red Blood Cell as a Model, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601538.ch10

Author Information

  1. Kawasaki College of Allied Health Professions, 316 Matsushima, Kurashiki City, 701-0194, Japan

Publication History

  1. Published Online: 29 APR 2004
  2. Published Print: 25 FEB 2003

ISBN Information

Print ISBN: 9783527304639

Online ISBN: 9783527601530

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Keywords:

  • hereditary spherocytosis;
  • epidemiology;
  • genetics;
  • gene mutations;
  • spectrin;
  • ankyrin;
  • band 3;
  • protein 4.2 deficiency;
  • spectrin deficiency;
  • spherocytosis;
  • membrane transport

Summary

This chapter contains sections titled:

  • Definition and History

  • Clinical and Laboratory Findings

  • Epidemiology and Genetics

  • Pathogenesis: Affected Proteins and Their Related Gene Mutations

    • Combined Partial Deficiency of Spectrin and Ankyrin Due to Ankyrin Gene Mutations

    • Partial Deficiency of Band 3 Due to the Band 3 Gene Mutations

    • Protein 4.2 Deficiency

    • Isolated Partial Spectrin Deficiency

  • Cellular Phenotypes: Spherocytosis and Membrane Transport

  • Role of the Spleen

  • Complications

  • Therapy and Prognosis