Chapter 19. Proteomic Applications for Molecular Assessment of Alzheimer's Disease

  1. Dr. Jean-Charles Sanchez,
  2. Dr. Garry L. Corthals,
  3. Prof. Dr. Denis F. Hochstrasser
  1. Dr. Odile Carrette1,
  2. Pierre R. Burkhard MD2,
  3. Prof. Dr. Denis F. Hochstrasser3,
  4. Dr. Jean-Charles Sanchez3

Published Online: 20 SEP 2004

DOI: 10.1002/3527601562.ch19

Book Title

Biomedical Applications of Proteomics

Biomedical Applications of Proteomics

Additional Information

How to Cite

Carrette, O., Burkhard, P. R., Hochstrasser, D. F. and Sanchez, J.-C. (2004) Proteomic Applications for Molecular Assessment of Alzheimer's Disease, in Biomedical Applications of Proteomics (eds J.-C. Sanchez, G. L. Corthals and D. F. Hochstrasser), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601562.ch19

Editor Information

  1. Biomedical Proteomics Research Group, Laboratoire Central de Chimie Clinique, Hopitaux Universitaires de Genève, 24, rue Micheli-du-Crest, 1211 Genève 14, Switzerland

Author Information

  1. 1

    Biomedical Proteomics Research Group, LCCC, Genève University Hospital, 24, rue Micheli-du-Crest, 1211 Genève 14, Switzerland

  2. 2

    Laboratory of CSF 2-DE, Department of Neurology, University Hospital — HUG, 24, rue Micheli-du-Crest, 1211 Genève 14, Switzerland

  3. 3

    Biomedical Proteomics Research Group, Laboratoire Central de Chimie Clinique, Hopitaux Universitaires de Genève, 24, rue Micheli-du-Crest, 1211 Genève 14, Switzerland

Publication History

  1. Published Online: 20 SEP 2004
  2. Published Print: 27 JAN 2004

ISBN Information

Print ISBN: 9783527308071

Online ISBN: 9783527601561

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Keywords:

  • Alzheimer's disease;
  • proteomic applications;
  • screening studies;
  • Tau protein;
  • amyloid precursor protein;
  • antioxidant response;
  • SELDI

Summary

  • Introduction

  • Two-dimensional Gel Electrophoresis Studies

    • General Screening Studies

    • Tau Protein

    • Amyloid Precursor Protein

    • Oxidative Stress and Antioxidant Response

  • SELDI

    • Amyloid Beta Peptide Analyzed by SELDI

    • Screening of AD with SELDI on a Strong Anionic Exchange Surface

    • Screening of AD, FTD, LBD, and VD with SELDI on a Weak Cationic Exchange (WCX2) Surface

  • Conclusions

  • Acknowledgements

  • References

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