Chapter 2. Antibody-Based Vascular Targeting: Proteomic Techniques for the Identification and Quantification of Membrane Proteins on Endothelial Cells

  1. Dr. Jean-Charles Sanchez,
  2. Dr. Garry L. Corthals,
  3. Prof. Dr. Denis F. Hochstrasser
  1. Simone Scheurer1,
  2. Jascha-Nikolai Rybak1,
  3. Christoph Roesli1,
  4. Dr. Giuliano Elia2,
  5. Prof. Dr. Dario Neri3

Published Online: 20 SEP 2004

DOI: 10.1002/3527601562.ch2

Book Title

Biomedical Applications of Proteomics

Biomedical Applications of Proteomics

Additional Information

How to Cite

Scheurer, S., Rybak, J.-N., Roesli, C., Elia, G. and Neri, D. (2004) Antibody-Based Vascular Targeting: Proteomic Techniques for the Identification and Quantification of Membrane Proteins on Endothelial Cells, in Biomedical Applications of Proteomics (eds J.-C. Sanchez, G. L. Corthals and D. F. Hochstrasser), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601562.ch2

Editor Information

  1. Biomedical Proteomics Research Group, Laboratoire Central de Chimie Clinique, Hopitaux Universitaires de Genève, 24, rue Micheli-du-Crest, 1211 Genève 14, Switzerland

Author Information

  1. 1

    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Irchel, Y17 M86, Winterthurerstrasse 190, 8057 Zurich, Switzerland

  2. 2

    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Irchel, Y17 M03, Winterthurerstrasse 190, 8057 Zurich, Switzerland

  3. 3

    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Irchel, Y36 M14, Winterthurerstrasse 190, 8057 Zurich, Switzerland

Publication History

  1. Published Online: 20 SEP 2004
  2. Published Print: 27 JAN 2004

ISBN Information

Print ISBN: 9783527308071

Online ISBN: 9783527601561

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CHAPTER TOOLS

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Keywords:

  • proteomic techniques;
  • vascular targeting;
  • quantitation of membrane proteins;
  • angiogenesis;
  • markers;
  • profiling

Summary

  • Introduction

  • Vascular Targeting

    • Angiogenesis

    • Angiogenesis-related Disorders

    • Markers of Angiogenesis

    • Ligand-based Vascular Targeting

  • Technologies for the Quantitation of Membrane Proteins in Different Cell Types

    • Gel-based Quantitative Profiling of Membrane Proteins

    • Gel-independent Quantitative Profiling of Membrane Proteins

  • Model Systems for the Identification of Vascular Targets

    • In vitro Model Systems for the Study of Gene Expression in Response to Environmental Changes

    • In vivo Model Systems for the Identification of Vascular Targets

  • Conclusions

  • Acknowledgements

  • References

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