Chapter 1. The Regulation of Gene Expression

  1. Prof. Dr. Gerhard Krauss

Published Online: 11 MAY 2004

DOI: 10.1002/3527601864.ch1

Biochemistry of Signal Transduction and Regulation, Third Edition

Biochemistry of Signal Transduction and Regulation, Third Edition

How to Cite

Krauss, G. (2003) The Regulation of Gene Expression, in Biochemistry of Signal Transduction and Regulation, Third Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601864.ch1

Author Information

  1. Laboratorium für Biochemie, Universität Bayreuth, 95440 Bayreuth, Germany

Publication History

  1. Published Online: 11 MAY 2004
  2. Published Print: 7 AUG 2003

ISBN Information

Print ISBN: 9783527305919

Online ISBN: 9783527601868



  • gene expression;
  • transcription regulation;
  • protein-nucleic acid interactions;
  • protein-DNA interactions;
  • repressors;
  • activators;
  • eucaryotes;
  • procaryotes;
  • transcription initiation;
  • eucaryotic transcription;
  • principal pathways;
  • chromatin structure;
  • methylation of DNA;
  • post-transcriptional regulation;
  • polyadenylation;
  • splicing;
  • stability


This chapter contains sections titled:

  • Regulation of Gene Expression: How and Where? A Schematic Overview

  • Protein-Nucleic Acid Interactions as a Basis for Specific Gene Regulation

    • Structural Motifs of DNA-binding Proteins

    • The Nature of the Specific Interactions in Protein-Nucleic Acid Complexes

    • The Role of the DNA Conformation in Protein-DNA Interactions

    • Structure of the Recognition Sequence and Quaternary Structure of DNA-binding Proteins

  • The Principles of Transcription Regulation

    • Elements of Transcription Regulation

    • Functional Requirements for Repressors and Transcriptional Activators

    • Mechanisms for the Control of the Activity of DNA-binding Proteins

      • Binding of Effector Molecules

      • Binding of Inhibitory Proteins

      • Modification of Regulatory Proteins

      • Changes in the Concentration of Regulatory DNA-binding Proteins

  • Regulation of Transcription in Eucaryotes

    • Overview of Transcription Initiation in Procaryotes

    • The Basic Features of Eukaryotic Transcription

    • The Eucaryotic Transcription Apparatus

      • Structure of the Transcription Start Site and Regulatory Sequences

      • Elementary Steps of Eucaryotic Transcription

      • Formation of a Basal Transcription Apparatus from General Transcription Factors and RNA Polymerase

      • Phosphorylation of RNA Polymerase II and the Onset of Transcription

      • TFIIH – a Pivotal Regulatory Protein Complex

    • Regulation of Eucaryotic Transcription by DNA-binding Proteins

      • The Structure of Eucaryotic Transcriptional Activators

      • Concerted Action of Transcriptional Activators and Coactivators in the Regulation of Transcription

      • Interactions with the Transcription Apparatus

    • Regulation of the Activity of Transcriptional Activators

      • The Principal Pathways for the Regulation of Transcriptional Activators

      • Phosphorylation of Transcriptional Activators

      • Heterotypic Dimerization

      • Regulation by Binding of Effector Molecules

    • Specific Repression of Transcription

    • Chromatin Structure and Transcription Activation

    • Methylation of DNA

  • Post-transcriptional Regulation of Gene Expression

    • Modifications at the 5' and 3' Ends of the Pre-mRNA

    • Formation of Alternative mRNA by Alternative Polyadenylation and by Alternative Splicing

    • Regulation via Transport and Splicing of Pre-mRNA

    • Stability of the mRNA

    • Regulation at the Level of Translation