Chapter 13. Regulation of the Cell Cycle
Published Online: 11 MAY 2004
DOI: 10.1002/3527601864.ch13
Copyright © 2003 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Biochemistry of Signal Transduction and Regulation, Third Edition
Additional Information
How to Cite
Krauss, G. (2004) Regulation of the Cell Cycle, in Biochemistry of Signal Transduction and Regulation, Third Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601864.ch13
Publication History
- Published Online: 11 MAY 2004
- Published Print: 7 AUG 2003
ISBN Information
Print ISBN: 9783527305919
Online ISBN: 9783527601868
- Summary
- Chapter
Keywords:
- cell cycle;
- control mechanisms;
- cell cycle apparatus;
- cyclins;
- proteolysis;
- G1/S phase transition;
- G2/M transition;
- SCF complex;
- Cdc25 phosphatase;
- damage checkpoints
Summary
This chapter contains sections titled:
Overview of the Cell Cycle
Principles of Cell Cycle Control
Intrinsic Control Mechanisms
External Control Mechanisms
Critical Cell Cycle Events and Cell Cycle Transitions
Key Elements of the Cell Cycle Apparatus
Cyclin-dependent Protein Kinases, CDKs
Structure of CDKs and Regulation by Phosphorylation
Cyclins
Regulation of Cyclin Concentration
Structural Basis for CDK Activation
Inhibitors of CDKs: the CKIs
Substrates of CDKs
Multiple Regulation of CDKs
Regulation of the Cell Cycle by Proteolysis
Targeted Proteolysis by the SCF Complex
Proteolysis during Mitosis: the Anaphase-promoting Complex/Cyclosome
The G1/S Phase Transition
Function of the D-type Cyclins
Function of pRb in the Cell Cycle
Cell Cycle Control of DNA Replication
The G2/M Transition and Cdc25 Phosphatase
Summary of Cell Cycle Progression
The DNA Damage Checkpoints