Chapter 14. Malfunction of Signaling Pathways and Tumorigenesis: Oncogenes and Tumor Suppressor Genes

  1. Prof. Dr. Gerhard Krauss

Published Online: 11 MAY 2004

DOI: 10.1002/3527601864.ch14

Book Title

Biochemistry of Signal Transduction and Regulation, Third Edition

Biochemistry of Signal Transduction and Regulation, Third Edition

Additional Information

How to Cite

Krauss, G. (2004) Malfunction of Signaling Pathways and Tumorigenesis: Oncogenes and Tumor Suppressor Genes, in Biochemistry of Signal Transduction and Regulation, Third Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601864.ch14

Author Information

  1. Laboratorium für Biochemie, Universität Bayreuth, 95440 Bayreuth, Germany

Publication History

  1. Published Online: 11 MAY 2004
  2. Published Print: 7 AUG 2003

ISBN Information

Print ISBN: 9783527305919

Online ISBN: 9783527601868

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CHAPTER TOOLS

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Keywords:

  • malfunction of signaling pathways;
  • tumorigenesis;
  • oncogenes;
  • tumor suppressor genes;
  • oncogenic mutations;
  • tumor formation;
  • genetic changes;
  • epigenetic changes;
  • errors in function;
  • proto-oncogenes;
  • DNA repair;
  • tumor suppression;
  • retinoblastoma protein pRb;
  • p53 protein;
  • APC and Wnt/β-catenin signaling

Summary

This chapter contains sections titled:

  • General Aspects of Tumor Formation

    • Characteristics of Tumor Cells

    • Genetic Changes in Tumor Cells

    • Epigenetic Changes in Tumor Cells

    • Causes of Oncogenic Mutations

    • DNA Repair, DNA Damage Checkpoints, and Tumor Formation

    • Cell Division and Tumor Formation

  • Cell Division Activity, Errors in Function of Signal Proteins, and Tumor Formation

    • The Fate of a Cell: Quiescence, Division, or Death

  • Definition and General Function of Oncogenes and Tumor Suppressor Genes

    • Oncogenes and Proto-Oncogenes

    • Mechanisms of Activation of Proto-Oncogenes

    • Examples of the Functions of Oncogenes

  • Tumor Suppressor Genes: General Functions

  • DNA Repair, DNA Integrity and Tumor Suppression

  • The Retinoblastoma Protein pRb in Cancer

  • The p16INK4a Gene Locus and ARF

  • The Tumor Suppressor Protein p53

    • Structure and Biochemical Properties of the p53 Protein

    • Sequence-Specific DNA Binding of p53

    • Genes Regulated by p53

    • Activation, Regulation and Modulation of the Function of p53

    • Overview of p53 Regulation

    • The MDM2-p53 Network and Cancer

  • The Tumor Suppressor APC and Wnt/β-Catenin Signaling

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