Chapter 2. The Regulation of Enzyme Activity

  1. Prof. Dr. Gerhard Krauss

Published Online: 11 MAY 2004

DOI: 10.1002/3527601864.ch2

Book Title

Biochemistry of Signal Transduction and Regulation, Third Edition

Biochemistry of Signal Transduction and Regulation, Third Edition

Additional Information

How to Cite

Krauss, G. (2004) The Regulation of Enzyme Activity, in Biochemistry of Signal Transduction and Regulation, Third Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601864.ch2

Author Information

  1. Laboratorium für Biochemie, Universität Bayreuth, 95440 Bayreuth, Germany

Publication History

  1. Published Online: 11 MAY 2004
  2. Published Print: 7 AUG 2003

ISBN Information

Print ISBN: 9783527305919

Online ISBN: 9783527601868

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CHAPTER TOOLS

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Keywords:

  • enzyme activity;
  • regulation;
  • effector molecules;
  • allosteric regulation;
  • inhibitor proteins;
  • activator proteins;
  • phosphorylation;
  • ubiquitin system;
  • ubiquitin-proteasome pathway;
  • sumoylation

Summary

This chapter contains sections titled:

  • Enzymes as Catalysts

  • Regulation of Enzymes by Effector Molecules

  • Principal Features of Allosteric Regulation

  • Regulation of Enzyme Activity by Binding of Inhibitor and Activator Proteins

  • Regulation of Enzyme Activity by Phosphorylation

    • Regulation of Glycogen Phosphorylase by Phosphorylation

    • Regulation of Isocitrate Dehydrogenase (E. coli) by Phosphorylation

  • Regulation via the Ubiquitin-Proteasome Pathway

    • Components of the Ubiquitin System

    • Degradation in the Proteasome

    • Recognition of the Substrate in the Ubiquitin-Proteasome Degradation Pathway

    • Regulatory Function of Ubiquitin Conjugation and the Targeted Degradation of Proteins

  • Regulation of Proteins by Sumoylation

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