Chapter 4. Signaling by Nuclear Receptors

  1. Prof. Dr. Gerhard Krauss

Published Online: 11 MAY 2004

DOI: 10.1002/3527601864.ch4

Biochemistry of Signal Transduction and Regulation, Third Edition

Biochemistry of Signal Transduction and Regulation, Third Edition

How to Cite

Krauss, G. (2004) Signaling by Nuclear Receptors, in Biochemistry of Signal Transduction and Regulation, Third Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601864.ch4

Author Information

  1. Laboratorium für Biochemie, Universität Bayreuth, 95440 Bayreuth, Germany

Publication History

  1. Published Online: 11 MAY 2004
  2. Published Print: 7 AUG 2003

ISBN Information

Print ISBN: 9783527305919

Online ISBN: 9783527601868

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Keywords:

  • nuclear receptors;
  • signaling;
  • ligands;
  • HREs;
  • HRE-receptor complex;
  • transcriptional regulation;
  • variability;
  • steroid hormone receptors

Summary

This chapter contains sections titled:

  • Ligands of Nuclear Receptors

  • Principles of Signaling by Nuclear Receptors

  • Classification and Structure of Nuclear Receptors

    • DNA-Binding Elements of Nuclear Receptors, HREs

    • The DNA-Binding Domain of Nuclear Receptors

    • HRE Recognition and Structure of the HRE-Receptor Complex

    • Ligand-binding Domains

    • Transactivating Elements of the Nuclear Receptors

  • Mechanisms of Transcriptional Regulation by Nuclear Receptors

  • Regulation and Variability of Signaling by Nuclear Receptors

  • The Signaling Pathway of the Steroid Hormone Receptors

  • Signaling by Retinoids, Vitamin D3, and the T3-Hormone

    • Structure of the HREs of RXR Heterodimers

    • Complexity of the Interaction between HRE, Receptor and Hormone