Chapter 6. Intracellular Messenger Substances: “Second Messengers”

  1. Prof. Dr. Gerhard Krauss

Published Online: 11 MAY 2004

DOI: 10.1002/3527601864.ch6

Book Title

Biochemistry of Signal Transduction and Regulation, Third Edition

Biochemistry of Signal Transduction and Regulation, Third Edition

Additional Information

How to Cite

Krauss, G. (2004) Intracellular Messenger Substances: “Second Messengers”, in Biochemistry of Signal Transduction and Regulation, Third Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601864.ch6

Author Information

  1. Laboratorium für Biochemie, Universität Bayreuth, 95440 Bayreuth, Germany

Publication History

  1. Published Online: 11 MAY 2004
  2. Published Print: 7 AUG 2003

ISBN Information

Print ISBN: 9783527305919

Online ISBN: 9783527601868

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Keywords:

  • intracellular messengers;
  • cAMP;
  • cGMP;
  • inositol phospholipids;
  • inositol phosphates;
  • PI3-kinase;
  • Ca2+;
  • calmodulin;
  • diacylglycerol;
  • lipid messengers;
  • NO

Summary

This chapter contains sections titled:

  • General Functions of Intracellular Messenger Substances

  • cAMP

  • cGMP

  • Metabolism of Inositol Phospholipids and Inositol Phosphates

  • Inositol 1,4,5-Triphosphate and Release of Ca2+

    • Release of Ca2+ from Ca2+ Storage

    • Influx of Ca2+ from the Extracellular Region

    • Removal and Storage of Ca2+

    • Temporal and Spatial Changes in Ca2+ Concentration

  • Phosphatidyl Inositol Phosphates and PI3-Kinase

    • PI3-Kinases

    • The Messenger Substance PtdIns(3,4,5)P3

    • Akt Kinase and PtdIns(3,4,5)P3 Signaling

    • Functions of PtIns(4,5)P2

  • Ca2+ as a Signal Molecule

    • Calmodulin as a Ca2+ Receptor

    • Target Proteins of Ca2+/Calmodulin

    • Other Ca2+ Receptors

  • Diacylglycerol as a Signal Molecule

  • Other Lipid Messengers

  • The NO Signaling Molecule

    • Reactivity and Stability of NO

    • Synthesis of NO

    • Physiological Functions and Attack Points of NO

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