Chapter 7. Ser/Thr-Specific Protein Kinases and Protein Phosphatases

Summary

This chapter contains sections titled:

• Classification, Structure and Characteristics of Protein Kinases

  • General Classification and Function of Protein Kinases

  • Classification of Ser/Thr-specific Protein Kinases

• Structure and Regulation of Protein Kinases

  • Main Structural Elements of Protein Kinases

  • Substrate Binding and Recognition

  • Control of Protein Kinase Activity

• Protein Kinase A

  • Structure and Substrate Specificity of Protein Kinase A

  • Regulation of Protein Kinase A

• Protein Kinase C

  • Characterization and Classification

  • Structure and Activation of Protein Kinase C

  • Regulation of Protein Kinase C

  • Functions and Substrates of Protein Kinase C

• Ca²⁺/Calmodulin-dependent Protein Kinases

  • Importance and General Function

  • Structure and Autoregulation of CaM Kinase II

• Ser/Thr-specific Protein Phosphatases

  • Structure and Classification of Ser/Thr Protein Phosphatases

  • Regulation of Ser/Thr Protein Phosphatases

  • Protein Phosphatase I, PPI

  • Protein Phosphatase 2A, PP2A

  • Protein Phosphatase 2B, Calcineurin

• Regulation of Protein Phosphorylation by Subcellular Localization