Chapter 8. Signal Transmission via Transmembrane Receptors with Tyrosine-Specific Protein Kinase Activity

Summary

This chapter contains sections titled:

• Structure and Function of Receptor Tyrosine Kinases

  • General Structure and Classification

  • Ligand Binding and Activation

  • Structure and Activation of the Tyrosine Kinase Domain

  • Effector Proteins of the Receptor Tyrosine Kinases

  • Attenuation and Termination of RTK Signaling

• Protein Modules as Coupling Elements of Signal Proteins

  • SH2 Domains

  • Phosphotyrosine-binding Domain (PTB Domain)

  • SH3 Domains

  • Membrane-targeting Domains: Pleckstrin Homology (PH) Domains and FYVE Domains

  • Phosphoserine/Threonine-binding Domains

  • PDZ Domains

• Nonreceptor Tyrosine-specific Protein Kinases

  • Structure and General Function of Nonreceptor Tyrosine Kinases

  • Src Tyrosine Kinase and Abl Tyrosine Kinase

• Protein Tyrosine Phosphatases

  • Structure and Classification of Protein Tyrosine Phosphatases

  • Cooperation of Protein Tyrosine Phosphatases and Protein Tyrosine Kinases

  • Regulation of Protein Tyrosine Phosphatases

• Adaptor Molecules of Intracellular Signal Transduction