Chapter 4. Antibiotics and the Ribosome

  1. Dr. Robert E. Babine and
  2. Dr. Sherin S. Abdel-Meguid
  1. Jeffrey L. Hansen

Published Online: 20 FEB 2004

DOI: 10.1002/3527601872.ch4

Protein Crystallography in Drug Discovery

Protein Crystallography in Drug Discovery

How to Cite

Hansen, J. L. (2003) Antibiotics and the Ribosome, in Protein Crystallography in Drug Discovery (eds R. E. Babine and S. S. Abdel-Meguid), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601872.ch4

Editor Information

  1. Suntory Pharmaceutical Research Laboratories, LLC, Structural and Computational Chemistry, One Kendall Square, Bldg 700, Cambridge, MA 02139, USA

Author Information

  1. Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, 415 Bass Center, New Haven, CT 06520, USA

Publication History

  1. Published Online: 20 FEB 2004
  2. Published Print: 27 NOV 2003

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold3,
  2. Prof. Dr. Hugo Kubinyi4 and
  3. Prof. Dr. Gerd Folkers5

Series Editor Information

  1. 3

    Biomedical Research Center, Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstraße 1, 40225 Düsseldorf, Germany

  2. 4

    BASF AG Ludwigshafen, c/o Donnersbergstraße 9, 67256 Weisenheim am Sand, Germany

  3. 5

    Department of Applied Biosciences, ETH Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland

ISBN Information

Print ISBN: 9783527306787

Online ISBN: 9783527601875

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Keywords:

  • antibiotics;
  • ribosome;
  • tRNA;
  • peptidyl transferase activity;
  • MLSB antibiotics;
  • macrolides;
  • lincosamides;
  • streptogramins;
  • chloramphenicol;
  • nucleoside analogue antibiotics

Summary

This chapter contains sections titled:

  • Introduction

  • The Ribosome

    • Introduction

    • Binding of tRNA

    • Peptidyl Transferase Activity

    • Structure of the Ribosome

  • Antibiotics

    • Introduction

    • Antibiotics that Bind to the 50S Subunit

    • MLSB Antibiotics

    • Macrolides

      • Macrolides, 15- and 16-Membered

      • Binding Interactions Between the Lactone Ring and the Ribosome

      • Sugar Interactions with the Ribosome

      • A Covalent Bond

      • Macrolides, 14-Membered

      • Rational Drug Design of Macrolides

    • Lincosamides

    • Streptogramins

    • Chloramphenicol

    • Nucleoside Analogue Antibiotics

      • Puromycin

      • Aminoacyl-4-aminohexosyl-cytosine Antibiotics

    • Other Antibiotics that Bind to the 50S Subunit

      • Sparsomycin

      • Anisomycin

  • Prospects for Rational Drug Design of Antibiotics that Bind to the Ribosome