Chapter 9. Engineering Proteins to Promote Crystallization

  1. Dr. Robert E. Babine and
  2. Dr. Sherin S. Abdel-Meguid
  1. Lei Jin and
  2. Robert E. Babine

Published Online: 20 FEB 2004

DOI: 10.1002/3527601872.ch9

Protein Crystallography in Drug Discovery

Protein Crystallography in Drug Discovery

How to Cite

Jin, L. and Babine, R. E. (2003) Engineering Proteins to Promote Crystallization, in Protein Crystallography in Drug Discovery (eds R. E. Babine and S. S. Abdel-Meguid), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527601872.ch9

Editor Information

  1. Suntory Pharmaceutical Research Laboratories, LLC, Structural and Computational Chemistry, One Kendall Square, Bldg 700, Cambridge, MA 02139, USA

Author Information

  1. Suntory Pharmaceutical Research Laboratories, LLC, Structural and Computational Chemistry, One Kendall Square, Bldg 700, Cambridge, MA 02139, USA

Publication History

  1. Published Online: 20 FEB 2004
  2. Published Print: 27 NOV 2003

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold2,
  2. Prof. Dr. Hugo Kubinyi3 and
  3. Prof. Dr. Gerd Folkers4

Series Editor Information

  1. 2

    Biomedical Research Center, Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstraße 1, 40225 Düsseldorf, Germany

  2. 3

    BASF AG Ludwigshafen, c/o Donnersbergstraße 9, 67256 Weisenheim am Sand, Germany

  3. 4

    Department of Applied Biosciences, ETH Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland

ISBN Information

Print ISBN: 9783527306787

Online ISBN: 9783527601875

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Keywords:

  • engineering proteins;
  • crystallization;
  • protein heterogeneity;
  • truncation;
  • point mutation;
  • crystal packing

Summary

This chapter contains sections titled:

  • Introduction

  • Removing Protein Heterogeneity by Truncation

  • Removing Protein Heterogeneity by Point Mutation

  • Improving Crystal Packing by Point Mutation