Chapter 3. Scale-Up Studies in Asymmetric Transfer Hydrogenation

  1. Dr. Hans-Ulrich Blaser2,
  2. Dr. Elke Schmidt3
  1. John Blacker,
  2. Juliette Martin

Published Online: 13 JAN 2004

DOI: 10.1002/3527602151.ch11

Book Title

Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions

Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions

Additional Information

How to Cite

Blacker, J. and Martin, J. (2004) Scale-Up Studies in Asymmetric Transfer Hydrogenation, in Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions (eds H.-U. Blaser and E. Schmidt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602151.ch11

Editor Information

  1. 2

    Solvias AG, P.O. Box, CH-4002 Basel, Switzerland

  2. 3

    Syngenta Crop Protection AG, CH-4058 Basel, Switzerland

Author Information

  1. Avecia Process Technology, Leeds Road, P.O. Box 521, Huddersfield, HD2 5AG, UK

Publication History

  1. Published Online: 13 JAN 2004
  2. Published Print: 6 NOV 2003

ISBN Information

Print ISBN: 9783527306312

Online ISBN: 9783527602155

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CHAPTER TOOLS

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Keywords:

  • scale-up;
  • asymmetric transfer hydrogenation;
  • catalyst;
  • hydrogen donor;
  • substrate;
  • (R)-1-tetralol;
  • (S)-4-fluorophenylethanol;
  • (R)-N-diphenylphosphinyl-1-methylnaphthylamine

Summary

This chapter contains sections titled:

  • Background

  • The Catalytic System

    • Catalyst

    • Hydrogen Donor

    • Substrate

  • Process

    • Temperature

    • Reactant Concentration

    • Reaction Control

  • Case Studies

    • Example 1: (R)-1-Tetralol

    • Example 2: (S)-4-Fluorophenylethanol

    • Example 3: (R)-N-Diphenylphosphinyl-1-methylnaphthylamine

  • Conclusions

  • Acknowledgements

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