Chapter 1. Development of an Efficient Synthesis of Chiral 2-Hydroxy Acids

  1. Dr. Hans-Ulrich Blaser2,
  2. Dr. Elke Schmidt3
  1. Junhua Tao,
  2. Kevin McGee

Published Online: 13 JAN 2004

DOI: 10.1002/3527602151.ch18

Book Title

Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions

Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions

Additional Information

How to Cite

Tao, J. and McGee, K. (2004) Development of an Efficient Synthesis of Chiral 2-Hydroxy Acids, in Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions (eds H.-U. Blaser and E. Schmidt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602151.ch18

Editor Information

  1. 2

    Solvias AG, P.O. Box, CH-4002 Basel, Switzerland

  2. 3

    Syngenta Crop Protection AG, CH-4058 Basel, Switzerland

Author Information

  1. Pfizer Inc., Global Research and Development, La Jolla, San Diego, California, USA

Publication History

  1. Published Online: 13 JAN 2004
  2. Published Print: 6 NOV 2003

ISBN Information

Print ISBN: 9783527306312

Online ISBN: 9783527602155

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Keywords:

  • synthesis;
  • 2-hydroxy acids;
  • reactor set-up;
  • enzyme loading;
  • replenishment

Summary

This chapter contains sections titled:

  • Introduction

  • Results and Discussion

  • Conclusion

  • Experimental Section

    • General Remarks

    • Sodium 3-(4-Fluorophenyl)-2-oxo-propionate (6)

    • (R)-3-(4-Fluorophenyl)-2-hydroxy propionic acid (1)

    • Reactor Set-up and Preparation

    • Enzyme Loading and Replenishment

  • Acknowledgment

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