Chapter 2. Factors Influencing the Application of Literature Methods toward the Preparation of a Chiral trans-Cyclopropane Carboxylic Acid Intermediate during Development of a Melatonin Agonist

  1. Dr. Hans-Ulrich Blaser2,
  2. Dr. Elke Schmidt3
  1. Ambarish K. Singh,
  2. J. Siva Prasad,
  3. Edward J. Delaney

Published Online: 13 JAN 2004

DOI: 10.1002/3527602151.ch19

Book Title

Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions

Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions

Additional Information

How to Cite

Singh, A. K., Prasad, J. S. and Delaney, E. J. (2004) Factors Influencing the Application of Literature Methods toward the Preparation of a Chiral trans-Cyclopropane Carboxylic Acid Intermediate during Development of a Melatonin Agonist, in Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions (eds H.-U. Blaser and E. Schmidt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602151.ch19

Editor Information

  1. 2

    Solvias AG, P.O. Box, CH-4002 Basel, Switzerland

  2. 3

    Syngenta Crop Protection AG, CH-4058 Basel, Switzerland

Author Information

  1. Bristol-Myers Squibb, Process R & D, Pharmaceutical Institute, P.O. Box 191, New Brunswick, NJ 08903, USA

Publication History

  1. Published Online: 13 JAN 2004
  2. Published Print: 6 NOV 2003

ISBN Information

Print ISBN: 9783527306312

Online ISBN: 9783527602155

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CHAPTER TOOLS

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Keywords:

  • trans-cyclopropane carboxylic acid;
  • melatonin agonist;
  • commercialization

Summary

This chapter contains sections titled:

  • Introduction

  • Chemical Approach Employed During Preclinical Research and Development (Route A)

  • Chemical Approaches Employed to Support Early Clinical Development (Route B)

  • Development of Process Technology to Support Phase II/III Clinical Studies and Future Commercialization (Routes C and D)

    • Enzymatic Approaches to Convert 5 into 19

    • Chemical Approaches to Convert 5 into 19

  • Definition of Process Technology for the Optimal Route (Route D)

  • Summary and Conclusions

  • Acknowledgement

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