Chapter 4. Enantioselective Hydrogenation: Towards a Large-Scale Total Synthesis of (R,R,R)-α-Tocopherol
- Dr. Hans-Ulrich Blaser3,
- Dr. Elke Schmidt4
Published Online: 13 JAN 2004
DOI: 10.1002/3527602151.ch4
Copyright © 2004 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions
Additional Information
How to Cite
Netscher, T., Scalone, M. and Schmid, R. (2004) Enantioselective Hydrogenation: Towards a Large-Scale Total Synthesis of (R,R,R)-α-Tocopherol, in Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions (eds H.-U. Blaser and E. Schmidt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602151.ch4
Editor Information
- 3
Solvias AG, P.O. Box, CH-4002 Basel, Switzerland
- 4
Syngenta Crop Protection AG, CH-4058 Basel, Switzerland
Publication History
- Published Online: 13 JAN 2004
- Published Print: 6 NOV 2003
ISBN Information
Print ISBN: 9783527306312
Online ISBN: 9783527602155
- Summary
- Chapter
Keywords:
- enantioselective hydrogenation;
- synthesis;
- (R,R,R)-α-tocopherol;
- vitamin E;
- alcohols;
- diphosphane ligands
Summary
This chapter contains sections titled:
Introduction: Vitamin E as the Target
Routes to (2R,4′-R,8′R)-α-Tocopherol by Total Synthesis
Synthesis of Prochiral Allylic Alcohols
Asymmetric Hydrogenation of Prochiral Allylic Alcohols
Synthesis of the Diphosphane Ligands
Procedures for Stereochemical Analysis
Concluding Remarks
Acknowledgements