Chapter 7. 7-Aminocephalosporanic Acid – Chemical versus Enzymatic Production Process

  1. Dr. Hans-Ulrich Blaser2,
  2. Dr. Elke Schmidt3
  1. Thomas Bayer

Published Online: 13 JAN 2004

DOI: 10.1002/3527602151.ch7

Book Title

Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions

Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions

Additional Information

How to Cite

Bayer, T. (2004) 7-Aminocephalosporanic Acid – Chemical versus Enzymatic Production Process, in Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions (eds H.-U. Blaser and E. Schmidt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602151.ch7

Editor Information

  1. 2

    Solvias AG, P.O. Box, CH-4002 Basel, Switzerland

  2. 3

    Syngenta Crop Protection AG, CH-4058 Basel, Switzerland

Author Information

  1. Siemens AG, Industriepark Höchst, G 811, D-65926 Frankfurt am Main, Germany

Publication History

  1. Published Online: 13 JAN 2004
  2. Published Print: 6 NOV 2003

ISBN Information

Print ISBN: 9783527306312

Online ISBN: 9783527602155

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CHAPTER TOOLS

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Keywords:

  • 7-aminocephalosporanic acid;
  • synthesis;
  • chemical process;
  • biocatalytic process

Summary

This chapter contains sections titled:

  • Introduction

  • Synthesis of 7-ACA

    • The Chemical 7-ACA Route

    • Single Step Biocatalytic 7-ACA Synthesis

    • Two-step Biocatalytic 7-ACA Synthesis

    • Two-Step Biocatalytic Process

      • Oxidation

      • Deacylation

  • Comparison of Chemical and Two-Step Biocatalytic 7-ACA Process

  • Conclusion

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