Chapter 13. Pharmaceutical Applications of Biocatalysis

  1. Prof. Dr. Andreas Sebastian Bommarius1,
  2. Dr. Bettina R. Riebel2

Published Online: 28 JAN 2005

DOI: 10.1002/3527602364.ch13

Book Title

Biocatalysis

Biocatalysis

Additional Information

How to Cite

Bommarius, A. S. and Riebel, B. R. (2005) Pharmaceutical Applications of Biocatalysis, in Biocatalysis, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602364.ch13

Author Information

  1. 1

    School of Chemical and Biomolecular Engineering, Parker H. Petit Biotechnology Institute, Georgia Institute of Technology, 315 Ferst Drive, N. W. Atlanta, GA 30332-0363, USA

  2. 2

    Emory University School of Medicine, Whitehead Research Building, 615 Michael Street, Atlanta, GA 30322, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 28 JAN 2004

ISBN Information

Print ISBN: 9783527303441

Online ISBN: 9783527602360

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Keywords:

  • pharmaceutical applications;
  • enzyme inhibition for the fight against disease;
  • pharmacologically active compounds;
  • drugs;
  • chiral drugs;
  • non-chiral drugs;
  • biology of diseases;
  • β-lactam antibiotics;
  • cholesterol;
  • pulmonary emphysema;
  • osteoarthritis;
  • human leucocyte elastase (HLE);
  • AIDS;
  • reverse transcriptase;
  • HIV protease inhibitors;
  • antiinfectives;
  • anticholesterol drugs;
  • anti-AIDS drugs;
  • keto compounds;
  • Pen G acylase;
  • lipases;
  • esterases

Summary

  • Enzyme Inhibition for the Fight against Disease

    • Introduction

    • Procedure for the Development of Pharmacologically Active Compounds

    • Process for the Registration of New Drugs

    • Chiral versus Non-chiral Drugs

  • Enzyme Cascades and Biology of Diseases

    • β-Lactam Antibiotics

    • Inhibition of Cholesterol Biosynthesis (in part after Suckling, 1990)

    • Pulmonary Emphysema, Osteoarthritis: Human Leucocyte Elastase (HLE)

    • AIDS: Reverse Transcriptase and HIV Protease Inhibitors

  • Pharmaceutical Applications of Biocatalysis

    • Antiinfectives

    • Anticholesterol Drugs

    • Anti-AIDS Drugs

    • High Blood Pressure Treatment

  • Applications of Specific Biocatalytic Reactions in Pharma

    • Reduction of Keto Compounds with Whole Cells

    • Applications of Pen G Acylase in Pharma

    • Applications of Lipases and Esterases in Pharma

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