Chapter 16. Evolution of Biocatalytic Function

  1. Prof. Dr. Andreas Sebastian Bommarius1,
  2. Dr. Bettina R. Riebel2

Published Online: 28 JAN 2005

DOI: 10.1002/3527602364.ch16

Book Title

Biocatalysis

Biocatalysis

Additional Information

How to Cite

Bommarius, A. S. and Riebel, B. R. (2005) Evolution of Biocatalytic Function, in Biocatalysis, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602364.ch16

Author Information

  1. 1

    School of Chemical and Biomolecular Engineering, Parker H. Petit Biotechnology Institute, Georgia Institute of Technology, 315 Ferst Drive, N. W. Atlanta, GA 30332-0363, USA

  2. 2

    Emory University School of Medicine, Whitehead Research Building, 615 Michael Street, Atlanta, GA 30322, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 28 JAN 2004

ISBN Information

Print ISBN: 9783527303441

Online ISBN: 9783527602360

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Keywords:

  • biocatalytic function;
  • relatedness of proteins;
  • protein families;
  • gene duplication;
  • horizontal gene transfer (HGT);
  • α/β-barrel proteins;
  • mandelate;
  • α-ketoadipate;
  • Trp

Summary

  • Introduction

    • Congruence of Sequence, Function, Structure, and Mechanism

  • Search Characteristics for Relatedness in Proteins

    • Classification of Relatedness of Proteins: the -log Family

    • Classification into Protein Families

    • Dominance of Different Mechanisms

  • Evolution of New Function in Nature

    • Dual-Functionality Proteins

    • Gene Duplication

    • Horizontal Gene Transfer (HGT)

    • Circular Permutation

  • α/β-Barrel Proteins as a Model for the Investigation of Evolution

    • Why Study α/β-Barrel Proteins?

    • Example of Gene Duplication: Mandelate and a-Ketoadipate Pathways

    • Exchange of Function in the Aromatic Biosynthesis Pathways: Trp and His Pathways

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