Chapter 18. Artificial Enzymes

  1. Prof. Dr. Andreas Sebastian Bommarius1,
  2. Dr. Bettina R. Riebel2

Published Online: 28 JAN 2005

DOI: 10.1002/3527602364.ch18

Book Title

Biocatalysis

Biocatalysis

Additional Information

How to Cite

Bommarius, A. S. and Riebel, B. R. (2005) Artificial Enzymes, in Biocatalysis, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602364.ch18

Author Information

  1. 1

    School of Chemical and Biomolecular Engineering, Parker H. Petit Biotechnology Institute, Georgia Institute of Technology, 315 Ferst Drive, N. W. Atlanta, GA 30332-0363, USA

  2. 2

    Emory University School of Medicine, Whitehead Research Building, 615 Michael Street, Atlanta, GA 30322, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 28 JAN 2004

ISBN Information

Print ISBN: 9783527303441

Online ISBN: 9783527602360

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CHAPTER TOOLS

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Keywords:

  • artificial enzymes;
  • catalytic antibodies;
  • proteinaceous catalysts;
  • ribozymes;
  • proteinaceous enzyme mimics;
  • enzyme models (synzymes);
  • Diels–Alder reaction;
  • chiral chemical catalysts;
  • polyamino acids;
  • heterogenized chiral polymer catalysts;
  • immobilized chiral polymer catalysts;
  • dendrimers;
  • organometallic catalysts;
  • tandem enzyme organometallic catalysts

Summary

  • Catalytic Antibodies

    • Principle of Catalytic Antibodies: Connection between Chemistry and Immunology

    • Test Reaction Selection, Haptens, Mechanisms, Stabilization

    • Breadth of Reactions Catalyzed by Antibodies

  • Other Proteinaceous Catalysts: Ribozymes and Enzyme Mimics

    • Ribozymes: RNA World before Protein World?

    • Proteinaceous Enzyme Mimics

  • Design of Novel Enzyme Activity: Enzyme Models (Synzymes)

    • Introduction

    • Enzyme Models on the Basis of the Binding Step: Diels–Alder Reaction

    • Enzyme Models with Binding and Catalytic Effects

  • Heterogenized/Immobilized Chiral Chemical Catalysts

    • Overview of Different Approaches

    • Immobilization with Polyamino Acids as Chiral Polymer Catalysts

    • Immobilization on Resins or other Insoluble Carriers

    • Heterogenization with Dendrimers

    • Retention of Heterogenized Chiral Chemical Catalysts in a Membrane Reactor

    • Recovery of Organometallic Catalysts by Phase Change: Liquid–Liquid Extraction

  • Tandem Enzyme Organometallic Catalysts

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