Chapter 13. Somatic Gene Therapy – Advanced Biotechnology Products in Clinical Development

  1. Dr. Oliver Kayser,
  2. Prof. Dr. Rainer H. Müller
  1. Matthias Schweizer1,
  2. Egbert Flory1,
  3. Carsten Muenk1,
  4. Prof. Dr. Klaus Cichutek1,
  5. Dr. Uwe Gottschalk2

Published Online: 28 JAN 2005

DOI: 10.1002/3527602410.ch13

Book Title

Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications

Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications

Additional Information

How to Cite

Schweizer, M., Flory, E., Muenk, C., Cichutek, K. and Gottschalk, U. (2005) Somatic Gene Therapy – Advanced Biotechnology Products in Clinical Development, in Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications (eds O. Kayser and R. H. Müller), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602410.ch13

Editor Information

  1. Free University Berlin, Institute of Pharmacy, Pharmaceutical Technology, Biopharmacy & Biotechnology, Kelchstr. 31, 12169 Berlin, Germany

Author Information

  1. 1

    Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51–59, 63225 Langen, Germany

  2. 2

    Bayer AG, GB Pharma-Biotechnologie, Friedrich-Ebert-Straße 217, 42096 Wuppertal, Germany

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 28 JAN 2004

ISBN Information

Print ISBN: 9783527305544

Online ISBN: 9783527602414

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Keywords:

  • pharmaceutical biotechnology;
  • somatic gene therapy;
  • biotechnology products in clinical development;
  • gene transfer methods;
  • nonviral vectors;
  • naked nucleic acid;
  • viral vectors;
  • clinical use;
  • manufacture;
  • regulatory aspects;
  • gene transfer medicinal products

Summary

  • Introduction

  • Gene Transfer Methods

    • Nonviral Vectors and Naked Nucleic Acid

    • Viral Vectors

      • Retroviral Vectors

      • Lentiviral Vectors

      • Adenoviral Vectors

      • AAV (Adeno-associated Viral) Vectors

      • Poxvirus Vectors

  • Clinical Use

    • Overview on Clinical Gene Therapy Trials

    • Gene Therapy of Monogeneic Congenital Diseases

    • Tumor Gene Therapy

    • Gene Therapy of Cardiovascular Diseases

    • Preventive Vaccination and Gene Therapy of Infectious Diseases

    • Clinical Gene Therapy for the Treatment of Other Diseases

  • Manufacture and Regulatory Aspects

  • First Experience with the Clinical Use of Gene Transfer Medicinal Products

  • References

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