Chapter 15. Xenotransplanation in Pharmaceutical Biotechnology

  1. Dr. Oliver Kayser,
  2. Prof. Dr. Rainer H. Müller
  1. Prof. Dr. Gregory J. Brunn1,
  2. Prof. Dr. Jeffrey L. Platt2

Published Online: 28 JAN 2005

DOI: 10.1002/3527602410.ch15

Book Title

Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications

Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications

Additional Information

How to Cite

Brunn, G. J. and Platt, J. L. (2005) Xenotransplanation in Pharmaceutical Biotechnology, in Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications (eds O. Kayser and R. H. Müller), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602410.ch15

Editor Information

  1. Free University Berlin, Institute of Pharmacy, Pharmaceutical Technology, Biopharmacy & Biotechnology, Kelchstr. 31, 12169 Berlin, Germany

Author Information

  1. 1

    Transplantation Biology and the Departments of Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MI 55905, USA

  2. 2

    Transplantation Biology and the Departments of Pharmacology and Experimental Surgery, Immunology and Pediatrics, Mayo Clinic, Rochester, MI 55905, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 28 JAN 2004

ISBN Information

Print ISBN: 9783527305544

Online ISBN: 9783527602414

SEARCH

CHAPTER TOOLS

Get PDF (179K)

Keywords:

  • pharmaceutical biotechnology;
  • xenotransplanation;
  • pig as a source of tissues;
  • pig as a source of organs;
  • biologic response;
  • immunologic responses to xenotransplantation;
  • rejection;
  • complement activation;
  • accommodation;
  • cellular mediated immune responses;
  • physiologic hurdles;
  • zoonosis

Summary

  • The Pig as a Source of Tissues and Organs for Clinical Xenotransplantation

  • The Biologic and Immunologic Responses to Xenotransplantation

  • Hyperacute Rejection

  • Complement Activation

  • Acute Vascular Rejection

  • Accommodation

  • Cellular Mediated Immune Responses

  • Physiologic Hurdles to Xenotransplantation

  • Zoonosis

  • A Scenario for the Clinical Application of Xenotransplantation

  • Acknowledgments

  • References

Get PDF (179K)