Chapter 16. Sculpturing the Architecture of Mineralized Tissues: Tissue Engineering of Bone from Soluble Signals to Smart Biomimetic Matrices

  1. Dr. Oliver Kayser,
  2. Prof. Dr. Rainer H. Müller
  1. Dr. Ugo Ripamonti,
  2. Dr. Lentsha Nathaniel Ramoshebi,
  3. Dr. Janet Patton,
  4. June Teare,
  5. Thato Matsaba,
  6. Louise Renton

Published Online: 28 JAN 2005

DOI: 10.1002/3527602410.ch16

Book Title

Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications

Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications

Additional Information

How to Cite

Ripamonti, U., Nathaniel Ramoshebi, L., Patton, J., Teare, J., Matsaba, T. and Renton, L. (2005) Sculpturing the Architecture of Mineralized Tissues: Tissue Engineering of Bone from Soluble Signals to Smart Biomimetic Matrices, in Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications (eds O. Kayser and R. H. Müller), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602410.ch16

Editor Information

  1. Free University Berlin, Institute of Pharmacy, Pharmaceutical Technology, Biopharmacy & Biotechnology, Kelchstr. 31, 12169 Berlin, Germany

Author Information

  1. Bone Research Unit, Medical Research Council/University of the Witwatersrand, 7 York Road, Parktown, 2193 Johannesburg, South Africa

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 28 JAN 2004

ISBN Information

Print ISBN: 9783527305544

Online ISBN: 9783527602414

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CHAPTER TOOLS

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Keywords:

  • pharmaceutical biotechnology;
  • mineralized tissues;
  • tissue engineering of bone;
  • osteogenic soluble signals;
  • biomimetic matrices;
  • TGF-β-superfamily;
  • site–tissue specificity of bone induction;
  • TGF-β-isoforms;
  • treatment of systemic bone loss;
  • local induction of bone;
  • geometric induction of bone formation

Summary

  • Introduction

  • Osteogenic Soluble Signals of the TGF-β-Superfamily

  • Site–tissue Specificity of Bone Induction by TGF-β-Isoforms in the Primate

  • Treatment of Systemic Bone Loss by Local Induction of Bone

  • Geometric Induction of Bone Formation

  • Conclusion

  • Acknowledgments

  • References

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