Chapter 2. Procaryotic and Eucaryotic Cells in Biotech Production

  1. Dr. Oliver Kayser,
  2. Prof. Dr. Rainer H. Müller
  1. Dr. Stefan Pelzer1,
  2. Prof. Dr. Dirk Hoffmeister2,
  3. Prof. Dr. Irmgard Merfort3,
  4. Prof. Dr. Andreas Bechthold3

Published Online: 28 JAN 2005

DOI: 10.1002/3527602410.ch2

Book Title

Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications

Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications

Additional Information

How to Cite

Pelzer, S., Hoffmeister, D., Merfort, I. and Bechthold, A. (2005) Procaryotic and Eucaryotic Cells in Biotech Production, in Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications (eds O. Kayser and R. H. Müller), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602410.ch2

Editor Information

  1. Free University Berlin, Institute of Pharmacy, Pharmaceutical Technology, Biopharmacy & Biotechnology, Kelchstr. 31, 12169 Berlin, Germany

Author Information

  1. 1

    Combinature Biopharm AG, Robert-Rössle-Straße 10, 13125 Berlin, Germany

  2. 2

    The University of Wisconsin, School of Pharmacy, 777 Highland Avenue, Madison, WI 53705, USA

  3. 3

    Albert-Ludwigs-Universität Freiburg, Pharmazeutische Biologie, Stefan-Meier-Straße 19, 79104 Freiburg, Germany

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 28 JAN 2004

ISBN Information

Print ISBN: 9783527305544

Online ISBN: 9783527602414

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Keywords:

  • pharmaceutical biotechnology;
  • procaryotic cells;
  • eucaryotic cells;
  • biotech production;
  • actinomycetes;
  • antimicrobial drugs;
  • glycorandomization;
  • mutasynthesis;
  • Saccharomyces cerevisiae;
  • production of alcoholic beverages;
  • lactic acid production;
  • xylitol production;
  • strictosidine production;
  • production of statins;
  • cyclosporin production;
  • production of β-lactam antibiotics;
  • transgenic plants;
  • functional foods;
  • neutraceuticals;
  • plants as bioreactors

Summary

  • Introduction

  • Actinomycetes in Biotech Production

    • Actinomycetes: Producer of Commercially Important Drugs

    • Actinomycetes Genetics: The Basis for Understanding Antibiotic Biosynthesis

    • Urgent Needs for the Development of New Antimicrobial Drugs

    • Strategies for the Identification and Development of New Antimicrobial Drugs

      • Approaches to Explore Nature's Chemical Diversity

      • Exploiting the Enormous Genotypic Potential of Actinomycetes by “Genome Mining”

      • Generation of Novel Antibiotics by Targeted Manipulation of the Biosynthesis (Combinatorial Biosynthesis)

      • Novel Natural Compounds by Glycorandomization

      • Novel Natural Compounds by Mutasynthesis

  • Saccharomyces cerevisiae and Other Fungi in Biotech Production

    • Generation of Engineered Strains of Saccharomyces cerevisiae for the Production of Alcoholic Beverages

    • Generation of Engineered Strains of Saccharomyces cerevisiae for Lactic acid, Xylitol, and Strictosidine Production

    • The Use of Fungi in the Production of Statins, Cyclosporin, and β-Lactam Antibiotics

      • Statins

      • Cyclosporin

      • β-Lactams

  • Plants in Biotech Production

    • Transgenic Plants as Functional Foods or Neutraceuticals

    • Transgenic Plants and Plant Cell Culture as Bioreactors of Secondary Metabolites

    • Transgenic Plants as Bioreactors of Recombinant Proteins

  • References

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