Chapter 1. Synthetic Methodologies

  1. Prof. Dr. Chi-Huey Wong
  1. Chikako Saotome,
  2. Osamu Kanie

Published Online: 28 JAN 2005

DOI: 10.1002/3527602437.ch1

Book Title

Carbohydrate-Based Drug Discovery

Carbohydrate-Based Drug Discovery

Additional Information

How to Cite

Saotome, C. and Kanie, O. (2005) Synthetic Methodologies, in Carbohydrate-Based Drug Discovery (ed C.-H. Wong), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602437.ch1

Editor Information

  1. Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines RoadLa Jolla, CA 92037, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 26 AUG 2003

ISBN Information

Print ISBN: 9783527306329

Online ISBN: 9783527602438

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CHAPTER TOOLS

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Keywords:

  • synthetic methodologies;
  • synthetic efficiency;
  • accessibility

Summary

  • Introduction

  • Tactical Analysis for Overall Synthetic Efficiency

  • Methodological Improvements

    • Chemistry

    • Protecting Group Manipulations

    • Modulation of the Reactivity of Glycosyl Donors

    • Block Synthesis

  • Accessibility

    • Solution-based Chemistry

    • One-Pot Glycosylation

    • Solid-Phase Chemistry

      • Fundamentals of Solid-Phase Oligosaccharide Synthesis

      • The Support

      • Linkers to the Support

      • Protecting Groups used in Solid-Phase Oligosaccharide Synthesis

      • Solid-Phase Oligosaccharide Synthesis

      • Monitoring of Reaction Progress

    • Automation

  • Concluding Remarks

  • References

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