Chapter 10. Chemistry and Biochemistry of Asparagine-Linked Protein Glycosylation

  1. Prof. Dr. Chi-Huey Wong
  1. Barbara Imperiali,
  2. Vincent W.-F. Tai

Published Online: 28 JAN 2005

DOI: 10.1002/3527602437.ch10

Book Title

Carbohydrate-Based Drug Discovery

Carbohydrate-Based Drug Discovery

Additional Information

How to Cite

Imperiali, B. and Tai, V. W.-F. (2005) Chemistry and Biochemistry of Asparagine-Linked Protein Glycosylation, in Carbohydrate-Based Drug Discovery (ed C.-H. Wong), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602437.ch10

Editor Information

  1. Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines RoadLa Jolla, CA 92037, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 26 AUG 2003

ISBN Information

Print ISBN: 9783527306329

Online ISBN: 9783527602438

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Keywords:

  • asparagine-linked protein glycosylation;
  • chemistry;
  • biochemistry

Summary

  • Protein Glycosylation

    • Introduction

    • Asparagine-Linked Glycosylation and Oligosaccharyl Transferase

  • Small-Molecule Probes of the Biochemistry of Oligosaccharyl Transferase

    • Photoaffinity and Affinity Labeling of Oligosaccharyl Transferase

    • Investigation of Peptide-Based Substrate Analogues as Inhibitors of Oligosaccharyl Transferase

      • Inhibitors of N-Linked Glycosylation and Glycoprotein Processing

      • Peptide-Based Analogues and Inhibitors

      • Interim Summary

    • Investigation of Carbohydrate-Based Substrate Analogues as Probes of Oligosaccharyl Transferase Function

      • Possible Mechanisms for Glycosyl Transfer

      • Probing of the Mechanism of Oligosaccharyl Transferase with Potential Inhibitors

      • Interim Summary

  • Conclusions

  • References

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