Chapter 15. Chemistry, Biochemistry, and Pharmaceutical Potentials of Glycosaminoglycans and Related Saccharides

  1. Prof. Dr. Chi-Huey Wong
  1. Tasneem Islam,
  2. Robert J. Linhardt

Published Online: 28 JAN 2005

DOI: 10.1002/3527602437.ch15

Book Title

Carbohydrate-Based Drug Discovery

Carbohydrate-Based Drug Discovery

Additional Information

How to Cite

Islam, T. and Linhardt, R. J. (2005) Chemistry, Biochemistry, and Pharmaceutical Potentials of Glycosaminoglycans and Related Saccharides, in Carbohydrate-Based Drug Discovery (ed C.-H. Wong), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602437.ch15

Editor Information

  1. Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines RoadLa Jolla, CA 92037, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 26 AUG 2003

ISBN Information

Print ISBN: 9783527306329

Online ISBN: 9783527602438

SEARCH

CHAPTER TOOLS

Get PDF (416K)

Keywords:

  • glycosaminoglycans chemistry;
  • biochemistry and pharmaceutical potentials;
  • dermatan;
  • chondroitin sulfates;
  • hyaluronan;
  • keratan sulfate;
  • acidic polysaccharides

Summary

  • Introduction

    • Biological Activities

    • Heparin and Heparan Sulfate

      • Structure and Properties

      • Biosynthesis and Biological Functions

      • Applications of Heparin and Heparan Sulfate

  • Dermatan and Chondroitin Sulfates

    • Structure and Biological Role

    • Therapeutic Applications

      • Dermatan Sulfate

      • Chondroitin Sulfates

  • Hyaluronan

    • Structure and Properties

    • Tissue Distribution and Biosynthesis

    • Functions and Applications

      • Medical Applications

      • Hyaluronic Acid Biomaterials

  • Keratan Sulfate

    • Structure and Distribution

    • Chemistry and Biosynthesis of Linkage Regions

      • Keratan Sulfate on Cartilage Proteoglycans

      • Keratan Sulfate on Corneal Proteoglycans

    • Biological Roles of Keratan Sulfate

      • Role of KS in Macular Corneal Dystrophy

  • Other Acidic Polysaccharides

    • Acharan Sulfate

    • Fucoidins

    • Carrageenans

    • Sulfated Chitins

    • Dextran Sulfate

    • Alginates

    • Fully Synthetic Sulfated Molecules

      • Polymers

      • Small Sulfonated Molecules

  • Pharmaceutical Potential and Challenges

    • GAG-Based Agents Are Heterogenous

    • GAG-Based Agents and Sulfonated Analogues Have Low Bioavailability

    • GAGs Have a Myriad of Biological Activities

    • Carbohydrate-Based Drugs Are Expensive and Difficult to Prepare

  • Conclusion

  • References

Get PDF (416K)