Chapter 22. Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes

  1. Prof. Dr. Chi-Huey Wong
  1. Laura L. Kiessling,
  2. Jason K. Pontrello,
  3. Michael C. Schuster

Published Online: 28 JAN 2005

DOI: 10.1002/3527602437.ch22

Book Title

Carbohydrate-Based Drug Discovery

Carbohydrate-Based Drug Discovery

Additional Information

How to Cite

Kiessling, L. L., Pontrello, J. K. and Schuster, M. C. (2005) Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes, in Carbohydrate-Based Drug Discovery (ed C.-H. Wong), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602437.ch22

Editor Information

  1. Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines RoadLa Jolla, CA 92037, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 26 AUG 2003

ISBN Information

Print ISBN: 9783527306329

Online ISBN: 9783527602438

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CHAPTER TOOLS

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Keywords:

  • synthetic multivalent carbohydrate ligands;
  • effectors;
  • inhibitors;
  • biological processes

Summary

  • Introduction

    • Mechanisms of Binding of Multivalent Ligands

    • Investigating the Structure/Function Relationship of a Series of Ligand Classes

  • Multivalent Carbohydrate Ligands as Inhibitors

    • Multivalency with AB5 Toxins

      • Bundle's Decavalent Ligand for the E. coli Shiga-Like Toxin

      • Fan's Pentavalent Ligands for Cholera Toxin and the E.coli Heat-Labile Enterotoxin

    • Multivalency in Anti-adhesives

      • Low Molecular Weight Multivalent Carbohydrate Inhibitors of Bacterial Adhesion

      • Polymeric Multivalent Carbohydrate Inhibitors of Influenza Virus

    • Multivalent Carbohydrate Ligands as Inhibitors of Immune Responses

  • Multivalent Carbohydrate Ligands as Effectors

    • Low Molecular Weight Multivalent Effectors

    • Multivalency in Targeting Strategies

    • Multivalent Bacterial Chemoattractants

    • Multivalent Ligand-Mediated Cell Aggregation

    • Multivalent Ligands and the Selectins

  • Conclusions

  • References

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