Chapter 23. Glycosyltransferase Inhibitors

  1. Prof. Dr. Chi-Huey Wong
  1. Karl-Heinz Jung,
  2. Richard R. Schmidt

Published Online: 28 JAN 2005

DOI: 10.1002/3527602437.ch23

Book Title

Carbohydrate-Based Drug Discovery

Carbohydrate-Based Drug Discovery

Additional Information

How to Cite

Jung, K.-H. and Schmidt, R. R. (2005) Glycosyltransferase Inhibitors, in Carbohydrate-Based Drug Discovery (ed C.-H. Wong), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602437.ch23

Editor Information

  1. Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines RoadLa Jolla, CA 92037, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 26 AUG 2003

ISBN Information

Print ISBN: 9783527306329

Online ISBN: 9783527602438

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CHAPTER TOOLS

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Keywords:

  • glycosyltransferase inhibitors;
  • glycosyltransferase;
  • NDP-sugar donors;
  • NMP-sugar donors;
  • bisubstrate analogues as inhibitors

Summary

  • Introduction

  • Glycosyltransferases Utilizing NDP-Sugar Donors

    • Inverting Glycosyltransferases

      • β-Glucosyltransferases

      • β-Galactosyltransferases

      • β-N-Acetylglucosaminyltransferases

      • α-Fucosyltransferases

      • β-Glucuronosyltransferases

    • Retaining Glycosyltransferases

      • α-Galactosyltransferases

      • α-N-Acetylgalactosaminyltransferases

  • Glycosyltransferases Utilizing NMP-Sugar Donors

    • α(2–6)Sialyltransferases

    • α(2–3)Sialyltransferases and α(2–8)Sialyltransferases

  • Bisubstrate Analogues as Inhibitors

  • Conclusion

  • References

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